Hoshaw S J, Fyhrie D P, Takano Y, Burr D B, Milgrom C
Bone and Joint Center, Henry Ford Hospital, Detroit, MI 48202, USA.
J Biomech. 1997 May;30(5):521-4. doi: 10.1016/s0021-9290(96)00176-5.
Strain gages are the gold-standard for measurement of bone strains in vivo. The use of strain gages in humans, however, is limited by the need for surgery to implant them and by the use of cyanoacrylate adhesives to bond them to bone. Cyanoacrylate adhesives are not FDA approved for implantation in humans, making it difficult to justify their use in experimental procedures. To surmount this difficulty, a method was developed to bond strain gages to bone using an approved substance: polymethylmethacrylate (PMMA). The technique and the validating experiments are presented. The PMMA bonding method gave strain gage readings within an average of 0.25% (range 0-5%) of those found using cyanoacrylate bonding in a side by side comparison on cast acrylic. On bone, the PMMA bonding method produced results comparable to extensometer readings. This method of strain gage application is accurate and straightforward. It is currently being successfully used for in vivo strain measurements in both humans and animals for up to several days following gage application.
应变片是体内测量骨应变的金标准。然而，应变片在人体中的应用受到植入手术需求以及使用氰基丙烯酸酯粘合剂将其粘结到骨头上的限制。氰基丙烯酸酯粘合剂未获美国食品药品监督管理局（FDA）批准用于人体植入，这使得在实验过程中难以证明其使用的合理性。为克服这一困难，开发了一种使用已获批准的物质聚甲基丙烯酸甲酯（PMMA）将应变片粘结到骨头上的方法。本文介绍了该技术及验证实验。在铸型丙烯酸材料上进行的并排比较中，PMMA粘结方法得到的应变片读数与使用氰基丙烯酸酯粘结得到的读数平均相差0.25%（范围为0 - 5%）。在骨头上，PMMA粘结方法产生的结果与引伸计读数相当。这种应变片应用方法准确且简单。目前，在应用应变片后的数天内，该方法已成功用于人体和动物的体内应变测量。
