Caston J, Vasseur F, Delhaye-Bouchaud N, Mariani J
Laboratoire de Neurophysiologie Sensorielle, Faculté des Sciences, Université de Rouen, France.
Behav Neurosci. 1997 Feb;111(1):214-8. doi: 10.1037//0735-7044.111.1.214.
Lurcher mutant (+/Lc) mice exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nucleus while deep cerebellar nuclei are essentially intact. To discriminate the respective participation of the cerebellar cortex and deep structures in learning and memory, the authors subjected 3- to 6-month-old +/Lc mice to a delayed spontaneous alternation task to test their working and long-term spatial memories. Results show that wild type (+/+) mice alternated above chance even after a 1-hr delay between the forced and choice trials, whereas in +/Lc mice, long-term memory was impaired. Cerebellectomized +/+ mice behave as +/Lc mice (working memory was preserved but long-term memory was not), whereas in the cerebellectomized +/Lc mice, both working and long-term memories were altered. These results are discussed in terms of relationships between the cerebellum and the hippocampus.
蹒跚突变体（+/Lc）小鼠的小脑皮质和下橄榄核中神经元大量缺失，而小脑深部核团基本完好。为了区分小脑皮质和深部结构在学习和记忆中的各自作用，作者对3至6个月大的+/Lc小鼠进行了延迟自发交替任务，以测试它们的工作记忆和长期空间记忆。结果表明，即使在强制试验和选择试验之间延迟1小时后，野生型（+/+）小鼠的交替率仍高于随机水平，而在+/Lc小鼠中，长期记忆受损。小脑切除的+/+小鼠表现得与+/Lc小鼠一样（工作记忆得以保留，但长期记忆受损），而在小脑切除的+/Lc小鼠中，工作记忆和长期记忆均发生了改变。本文根据小脑与海马体之间的关系对这些结果进行了讨论。
