Pascal R R, Gramlich T L, Parker K M, Gansler T S
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
Mod Pathol. 1997 Apr;10(4):363-5.
We reviewed 256 mucosal biopsy specimens from the descending and sigmoid colon obtained from surgical pathology departments in several areas of the United States. Only specimens of normal colonic mucosa were included, i.e., no specimens with acute or chronic colitis or adenomatous change, or in which eosinophils invaded the crypts or muscularis mucosae. The mean number of eosinophils per intercryptal space was highest in the southern United States, and there was a 35-fold difference between the mean eosinophil concentrations of patients in New Orleans and Boston. The reason for geographic variation is unknown, but it might be related to allergens in the environment or diet. Normal variations in mucosal eosinophil concentrations should be measured within a specific region before evaluating colonic biopsy specimens for eosinophilia.
我们回顾了从美国多个地区外科病理科获取的256份降结肠和乙状结肠黏膜活检标本。仅纳入正常结肠黏膜标本，即无急性或慢性结肠炎、腺瘤样改变，或嗜酸性粒细胞未侵入隐窝或黏膜肌层的标本。美国南部每个隐窝间空间的嗜酸性粒细胞平均数量最高，新奥尔良和波士顿患者的嗜酸性粒细胞平均浓度相差35倍。地域差异的原因尚不清楚，但可能与环境或饮食中的过敏原有关。在评估结肠活检标本嗜酸性粒细胞增多情况之前，应在特定区域内测量黏膜嗜酸性粒细胞浓度的正常变化。
