在患有精神疾病的人类外周血白细胞中未能检测到博尔纳病病毒感染。

Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders.

作者信息

Richt J A, Alexander R C, Herzog S, Hooper D C, Kean R, Spitsin S, Bechter K, Schüttler R, Feldmann H, Heiske A, Fu Z F, Dietzschold B, Rott R, Koprowski H

机构信息

Institut für Virologie, Universitat Giessen, Germany.

出版信息

J Neurovirol. 1997 Apr;3(2):174-8. doi: 10.3109/13550289709015807.

DOI:10.3109/13550289709015807

PMID:9111180

Abstract

The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies concerning the detection of BDV-specific RNA in blood cells from patients with psychiatric diseases. Contrary to the results obtained by others, we have found no evidence for the presence of BDV-RNA in such cells. Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.

摘要

一些患有特定精神疾病的患者血清中存在与博尔纳病病毒（BDV）反应的抗体，这被视为该兽医嗜神经病毒可能偶尔感染人类并导致精神障碍的证据。在本文中，我们报告了关于检测精神疾病患者血细胞中BDV特异性RNA的研究结果。与其他人获得的结果相反，我们没有发现此类细胞中存在BDV-RNA的证据。检测环境中先前对BDV序列的研究，以及逆转录聚合酶链反应（RT-PCR）的高灵敏度，可能解释了BDV特异性RNA存在于人类血细胞中的假阳性证据的零星出现。