Thompson R J, Gustafson K E, Oehler J M, Catlett A T, Brazy J E, Goldstein R F
Department of Psychiatry, Duke University Medical Center, NC 27710, USA.
J Dev Behav Pediatr. 1997 Apr;18(2):91-6. doi: 10.1097/00004703-199704000-00003.
The continuing contribution of early biological and psychosocial risk factors to developmental outcome of 55 very low birth weight infants (< or = 1500 g) was assessed at 4 years of age. Biological risk, assessed by the Neurobiologic Risk Score, accounted for significant portions of the variance in the perceptual-performance (17%) and motor (35%) dimensions of the McCarthy Scales of Children's Abilities. Psychosocial risk, reflected in maternal appraisals of daily stress during the newborn period, did not account for a significant portion of variance in any of the McCarthy Scales. Maternal education level, however, another measure of psychosocial risk, accounted for significant portions of variance (from 6% to 34%) on each of the McCarthy Scales. Movement from low neurobiologic risk status to poor outcome status at 4 years of age was associated with a number of psychosocial variables, including maternal education and early levels of maternal daily stress. The findings are discussed in terms of early markers for very low birth weight infants who require careful follow-up and of potential intervention targets to promote developmental outcome.
对55名极低出生体重儿（≤1500克）4岁时的发育结果，评估了早期生物和心理社会风险因素的持续影响。通过神经生物学风险评分评估的生物风险，在儿童能力麦卡锡量表的感知 - 操作维度（17%）和运动维度（35%）的方差中占很大比例。心理社会风险，反映在母亲对新生儿期日常压力的评估中，在任何一项麦卡锡量表的方差中均未占很大比例。然而，母亲教育水平，作为心理社会风险的另一项衡量指标，在每项麦卡锡量表的方差中占很大比例（从6%到34%）。4岁时从低神经生物学风险状态转变为不良结果状态，与许多心理社会变量有关，包括母亲教育和母亲早期日常压力水平。根据需要密切随访的极低出生体重儿的早期标志物以及促进发育结果的潜在干预目标对研究结果进行了讨论。
