Kauhanen J, Kaplan G A, Goldberg D D, Cohen R D, Lakka T A, Salonen J T
Research Institute of Public Health, University of Kuopio, Finland.
Epidemiology. 1997 May;8(3):310-4. doi: 10.1097/00001648-199705000-00014.
We studied the relation between frequent hangovers and cardiovascular mortality in a representative population sample of middle-aged Finnish men who participated in the Kuopio Ischemic Heart Disease Risk Factor Study. Complete data on alcohol consumption, hangover frequency, prior cardiovascular diseases, and risk factors were obtained for 2,160 non-abstinent men. Frequent hangovers were rare in the three lowest alcohol consumption quartiles, but in the highest quartile, a total of 239 men (43.6%) reported having a hangover at least monthly. During an average follow-up time of 6.7 years, these men had a 2.36-fold (95% confidence interval = 1.02-5.48) risk of cardiovascular death compared with men with fewer hangovers, with adjustment for age and total alcohol consumption. The association was somewhat attenuated after adjustments for smoking, income, and prior cardiovascular diseases. Systolic blood pressure, body mass index, resting heart rate, or serum lipids had no appreciable role in the relation, but plasma fibrinogen concentration appeared as one possible pathway to increased risk of cardiovascular death in men who frequently experience hangovers. The findings underline the importance of preventive actions regarding not only the amount but also the way people consume alcohol.
我们在参与库奥皮奥缺血性心脏病危险因素研究的芬兰中年男性代表性人群样本中，研究了频繁宿醉与心血管疾病死亡率之间的关系。我们获取了2160名非戒酒男性关于饮酒量、宿醉频率、既往心血管疾病及危险因素的完整数据。在饮酒量最低的三个四分位数组中，频繁宿醉的情况较为罕见，但在最高四分位数组中，共有239名男性（43.6%）报告至少每月有一次宿醉。在平均6.7年的随访期内，与宿醉较少的男性相比，这些男性在调整年龄和总饮酒量后，心血管死亡风险高出2.36倍（95%置信区间=1.02 - 5.48）。在对吸烟、收入和既往心血管疾病进行调整后，这种关联有所减弱。收缩压、体重指数、静息心率或血脂在这种关系中没有明显作用，但血浆纤维蛋白原浓度似乎是频繁宿醉男性心血管死亡风险增加的一条可能途径。这些发现强调了不仅要关注饮酒量，还要关注饮酒方式的预防措施的重要性。
