Verster Joris C, Stephens Richard, Penning Renske, Rohsenow Damaris, McGeary John, Levy Dan, McKinney Adele, Finnigan Frances, Piasecki Thomas M, Adan Ana, Batty G David, Fliervoet Lies A L, Heffernan Thomas, Howland Jonathan, Kim Dai-Jin, Kruisselbrink L Darren, Ling Jonathan, McGregor Neil, Murphy René J L, van Nuland Merel, Oudelaar Marieke, Parkes Andrew, Prat Gemma, Reed Nick, Slutske Wendy S, Smith Gordon, Young Mark
Utrecht University, Utrecht Institute for Pharmaceutical Science, Division of Pharmacology, Utrecht, The Neterlands.
Curr Drug Abuse Rev. 2010 Jun;3(2):116-26. doi: 10.2174/1874473711003020116.
Alcohol-induced hangover, defined by a series of symptoms, is the most commonly reported consequence of excessive alcohol consumption. Alcohol hangovers contribute to workplace absenteeism, impaired job performance, reduced productivity, poor academic achievement, and may compromise potentially dangerous daily activities such as driving a car or operating heavy machinery. These socioeconomic consequences and health risks of alcohol hangover are much higher when compared to various common diseases and other health risk factors. Nevertheless, unlike alcohol intoxication the hangover has received very little scientific attention and studies have often yielded inconclusive results. Systematic research is important to increase our knowledge on alcohol hangover and its consequences. This consensus paper of the Alcohol Hangover Research Group discusses methodological issues that should be taken into account when performing future alcohol hangover research. Future research should aim to (1) further determine the pathology of alcohol hangover, (2) examine the role of genetics, (3) determine the economic costs of alcohol hangover, (4) examine sex and age differences, (5) develop common research tools and methodologies to study hangover effects, (6) focus on factor that aggravate hangover severity (e.g., congeners), and (7) develop effective hangover remedies.
酒精性宿醉是过量饮酒最常报告的后果，由一系列症状所定义。酒精性宿醉会导致工作缺勤、工作表现受损、生产力下降、学业成绩不佳，还可能危及如开车或操作重型机械等潜在危险的日常活动。与各种常见疾病和其他健康风险因素相比，酒精性宿醉的这些社会经济后果和健康风险要高得多。然而，与酒精中毒不同，宿醉很少受到科学关注，研究结果往往尚无定论。系统研究对于增加我们对酒精性宿醉及其后果的了解很重要。酒精性宿醉研究小组的这份共识文件讨论了在未来进行酒精性宿醉研究时应考虑的方法学问题。未来的研究应旨在：（1）进一步确定酒精性宿醉的病理；（2）研究遗传学的作用；（3）确定酒精性宿醉的经济成本；（4）研究性别和年龄差异；（5）开发研究宿醉影响的通用研究工具和方法；（6）关注加重宿醉严重程度的因素（如同系物）；（7）开发有效的宿醉补救措施。
