来自假马齿苋的达玛烷型三萜皂苷。

Dammarane-type triterpenoid saponins from Bacopa monniera.

作者信息

Garai S, Mahato S B, Ohtani K, Yamasaki K

机构信息

Indian Institute of Chemical Biology, Calcutta, India.

出版信息

Phytochemistry. 1996 Jun;42(3):815-20. doi: 10.1016/0031-9422(95)00936-1.

DOI:10.1016/0031-9422(95)00936-1

PMID:8768327

Abstract

Three new dammarane-type triterpenoid saponins, bacopasaponins A, B and C, of biological interest have been isolated from the reputed Indian medicinal plant Bacopa monniera and identified as 3-O-alpha-L-arabinopyranosyl-20-O-alpha-L-arabinopyranosyl-+ ++jujubogenin, 3-O-[alpha-L-arabinofuranosyl (1--> 2)alpha-L-arabinopyranosyl]pseudojujubogenin and 3-O-[beta-D-glucopyranosyl (1 -->3)[alpha-L-arabinofuranosyl (1--> 2)]alpha-L-arabinopyranosyl]pseudojujubogenin by spectroscopic methods and some chemical transformations. The hitherto undetermined configurations at C-20 and C-22 of pseudojujubogenin were elucidated by phase-sensitive ROESY, and 1H and 13C signals of the saponins were assigned by DEPT, 1H-1H COSY, HSQC and HMBC techniques.

摘要

从著名的印度药用植物假马齿苋中分离出了三种具有生物学意义的新达玛烷型三萜皂苷，即假马齿苋皂苷A、B和C，并通过光谱方法和一些化学转化将它们鉴定为3-O-α-L-阿拉伯吡喃糖基-20-O-α-L-阿拉伯吡喃糖基酸枣仁皂苷元、3-O-[α-L-阿拉伯呋喃糖基(1→2)α-L-阿拉伯吡喃糖基]假酸枣仁皂苷元和3-O-[β-D-葡萄糖吡喃糖基(1→3)[α-L-阿拉伯呋喃糖基(1→2)]α-L-阿拉伯吡喃糖基]假酸枣仁皂苷元。通过相敏ROESY阐明了假酸枣仁皂苷元C-20和C-22处迄今未确定的构型，并通过DEPT、1H-1H COSY、HSQC和HMBC技术对皂苷的1H和13C信号进行了归属。