小鼠S10基因的结构与表达

Structure and expression of the mouse S10 gene.

作者信息

Zheng J Y, Koda T, Arimura Y, Kishi M, Kakinuma M

机构信息

Institute of Immunological Science, Hokkaido University, Sapporo, Japan.

出版信息

Biochim Biophys Acta. 1997 Mar 20;1351(1-2):47-50. doi: 10.1016/s0167-4781(97)00022-5.

DOI:10.1016/s0167-4781(97)00022-5

PMID:9116044

Abstract

We previously reported the cloning of a human S10 cDNA which encodes a small GTP-binding protein belonging to the Rab subfamily. Here we describe a mouse S10 cDNA and its genomic structure. Mouse S10 is 92.3% homologous at the nucleotide level and 98.3% identical at the amino acid level compared to human S10. The mouse S10 gene is comprised of two exons and a single intron. Northern blotting of tissue RNAs indicates that the S10 gene is predominantly expressed in brain.

摘要

我们先前报道了人类S10 cDNA的克隆，该cDNA编码一种属于Rab亚家族的小GTP结合蛋白。在此，我们描述小鼠S10 cDNA及其基因组结构。与人类S10相比，小鼠S10在核苷酸水平上具有92.3%的同源性，在氨基酸水平上具有98.3%的同一性。小鼠S10基因由两个外显子和一个内含子组成。组织RNA的Northern印迹分析表明，S10基因主要在脑中表达。