编码一种小GTP结合蛋白（RAS超家族成员）的人类cDNA（RAB7L1）的克隆及染色体定位到1q32 。
Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily.
作者信息
Shimizu F, Katagiri T, Suzuki M, Watanabe T K, Okuno S, Kuga Y, Nagata M, Fujiwara T, Nakamura Y, Takahashi E
机构信息
Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
出版信息
Cytogenet Cell Genet. 1997;77(3-4):261-3. doi: 10.1159/000134591.
A full-length cDNA homologous to RAB7, a member of the RAB-related GTP-binding protein subfamily, was isolated from a human placenta cDNA library. This cDNA, designated RAB7L1, has an open reading frame of 609 nucleotides encoding 203 amino acids. Northern analysis showed that the mRNA is ubiquitously expressed in human tissues, although signal intensities were different among the various organs examined. This gene was located on chromosome band 1q32 by fluorescence in situ hybridization.
从人胎盘cDNA文库中分离出一个与RAB相关GTP结合蛋白亚家族成员RAB7同源的全长cDNA。该cDNA命名为RAB7L1，具有一个609个核苷酸的开放阅读框，编码203个氨基酸。Northern分析表明，该mRNA在人体组织中普遍表达，尽管在所检测的各个器官中信号强度有所不同。通过荧光原位杂交将该基因定位在染色体1q32带上。
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