B细胞一个功能亚群上的抗原标记，受H-2复合体的I-A亚区控制。
Antigenic marker on a functional subpopulation of B cells, controlled by the I-A subregion of the H-2 complex.
作者信息
Huber B T
出版信息
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3460-3. doi: 10.1073/pnas.76.7.3460.
Abstract
CBA/N mice have an X-linked recessive effect that results in the absence of a subpopulation of B cells carrying the Lyb3 surface marker. It has been shown previously that this marker is present on a mature subset of B cells in all mouse strains. In this paper the Lyb3+ B cell population in C57BL/6 mice was analyzed further. This subset of B cells selectively expresses a surface marker controlled by the I-A subregion of the H-2 complex. A cytotoxic antiserum recognizing this marker was raised by immunizing defective (CBA/N X C57BL/6)F1 male mice with C57BL/6 spleen cells. This antiserum also contained noncytotoxic, non-strain-restricted anti-Lyb3 antibodies. The possible functional relevance of this surface marker is discussed.
摘要
CBA/N小鼠具有X连锁隐性效应，导致缺乏携带Lyb3表面标志物的B细胞亚群。先前已表明，该标志物存在于所有小鼠品系的成熟B细胞亚群上。本文进一步分析了C57BL/6小鼠中的Lyb3+B细胞群体。该B细胞亚群选择性表达受H-2复合体I-A亚区控制的表面标志物。通过用C57BL/6脾细胞免疫缺陷型（CBA/N×C57BL/6）F1雄性小鼠，制备了识别该标志物的细胞毒性抗血清。该抗血清还含有非细胞毒性、非品系限制性的抗Lyb3抗体。文中讨论了该表面标志物可能的功能相关性。
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Antigenic marker on a functional subpopulation of B cells, controlled by the I-A subregion of the H-2 complex.B细胞一个功能亚群上的抗原标记，受H-2复合体的I-A亚区控制。
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