诺米芬辛简介。
A profile of nomifensine.
作者信息
Hanks G W
出版信息
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):243S-248S. doi: 10.1111/j.1365-2125.1977.tb05760.x.
Abstract
- Nomifensine is a new antidepressant of novel chemical structure (a tetrahydroisoquinoline) with a pharmacological and therapeutic profile which differentiates it from any existing group of psychotropic agents. 2. The basic animal pharmacological profile is similar to that of the tricyclic antidepressants, imipramine and desmethylimipramine, but with a comparative lack of peripheral anticholinergic and cardiotoxic effects. 3. The pattern of effects on monoamine neurotransmitters is unique amongst antidepressants in that nomifensine is a potent dopamine agonist, has a powerful inhibitory effect on noradrenaline uptake and a weaker inhibitory effect on serotonin uptake. These pharmacological differences are reflected in the behavioural activity of the drug. 4. Clinically nomifensine has been shown to be an effective non-sedative antidepressant; its relative lack of anticholinergic and other somatic side-effects (particularly on the cardiovascular system) have been confirmed in patients.
摘要
- 诺米芬辛是一种具有新型化学结构（四氢异喹啉）的新型抗抑郁药，其药理和治疗特性使其有别于现有的任何一类精神药物。2. 其基本的动物药理特性与三环类抗抑郁药丙咪嗪和去甲丙咪嗪相似，但相对缺乏外周抗胆碱能和心脏毒性作用。3. 它对单胺类神经递质的作用模式在抗抑郁药中是独特的，因为诺米芬辛是一种强效多巴胺激动剂，对去甲肾上腺素摄取有强大的抑制作用，对5-羟色胺摄取的抑制作用较弱。这些药理差异反映在该药的行为活性上。4. 在临床上诺米芬辛已被证明是一种有效的非镇静性抗抑郁药；患者已证实其相对缺乏抗胆碱能和其他躯体副作用（特别是对心血管系统）。
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