诺米芬辛药理学的比较综述。
A comparative review of the pharmacology of nomifensine.
作者信息
Hoffmann I
出版信息
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):69S-75S. doi: 10.1111/j.1365-2125.1977.tb05762.x.
Abstract
- Nomifensine is a new substance which showed, in tests for antidepressant activity, a pronounced effect which is quantitatively better than that of the reference substances. 2. With regard to thymoleptic effects in animal studies the effect of nomifensine is similar to that of tricyclic antidepressants, but nomifensine has no pronounced anticholinergic activity. 3. Nomifensine influences the cardiovascular system very slightly. 4. The mechanism of action of nomifensine differs from that of tricyclic antidepressants and must be clearly differentiated from phenylalkyl amines with sympathomimetric activity. 5. Nomifensine is a compound with a special, new profile of action, and thus cannot be calssified in known categories.
摘要
- 诺米芬辛是一种新物质，在抗抑郁活性测试中显示出明显效果，在数量上优于参比物质。2. 在动物研究中，就抗抑郁作用而言，诺米芬辛的效果与三环类抗抑郁药相似，但诺米芬辛没有明显的抗胆碱能活性。3. 诺米芬辛对心血管系统的影响非常轻微。4. 诺米芬辛的作用机制与三环类抗抑郁药不同，必须与具有拟交感活性的苯烷基胺明确区分开来。5. 诺米芬辛是一种具有特殊新作用谱的化合物，因此不能归类于已知类别。
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