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1
Induction, establishment in vitro, and characterization of functional, antigen-specific, carrier-primed murine T-cell lymphomas.功能性、抗原特异性、载体致敏小鼠T细胞淋巴瘤的诱导、体外建立及特性分析
Proc Natl Acad Sci U S A. 1979 Aug;76(8):4033-7. doi: 10.1073/pnas.76.8.4033.
2
Epitope-specific regulation. I. Carrier-specific induction of suppression for IgG anti-hapten antibody responses.表位特异性调节。I. 针对IgG抗半抗原抗体应答的载体特异性抑制诱导。
J Exp Med. 1982 Jun 1;155(6):1730-40. doi: 10.1084/jem.155.6.1730.
3
Regulation of anti-hapten antibody responses in vivo: memory, carrier-specific Lyt-2+ T cells can terminate antibody production without altering the peak of response.体内抗半抗原抗体反应的调节：记忆性、载体特异性Lyt-2⁺ T细胞可终止抗体产生而不改变反应峰值。
J Immunol. 1984 Apr;132(4):1639-46.
4
Antigen requirements for induction of B-memory cells: studies with dinitrophenyl coupled to T-dependent and T-independent carriers.诱导B记忆细胞的抗原需求：与偶联于T细胞依赖性和T细胞非依赖性载体的二硝基苯基的研究
J Exp Med. 1978 Jun 1;147(6):1824-31. doi: 10.1084/jem.147.6.1824.
5
Immortalization of antigen specific, helper T cell lines by transformation with the radiation leukemia virus (RadLV).
J Immunol. 1982 Feb;128(2):625-8.
6
Murine B-cell subpopulations responsive to T-dependent and T-independent antigens.对T细胞依赖性和T细胞非依赖性抗原产生反应的小鼠B细胞亚群。
J Exp Med. 1976 Aug 1;144(2):382-97. doi: 10.1084/jem.144.2.382.
7
Reaginic antibody formation in the mouse. V. Adoptive antihapten IgE antibody response of dinitrophenyl-keyhole limpet hemocyanin-primed spleen cells cultured with dinitrophenyl heterologous carrier conjugates.小鼠体内反应素性抗体的形成。V. 用二硝基苯基-异源载体偶联物培养经二硝基苯基-钥孔戚血蓝蛋白致敏的脾细胞的过继抗半抗原IgE抗体反应
J Immunol. 1975 Feb;114(2 Pt 1):615-20.
8
Studies on B-cell memory. II. T-cell independent antigen can induce B-cell memory.B细胞记忆的研究。II. 非T细胞依赖性抗原可诱导B细胞记忆。
Immunology. 1979 Oct;38(2):291-9.
9
Genetic control of sensitivity to moloney leukemia virus in mice. VI. Involvement of virus-specific T helper cells collaborating with B cells.小鼠对莫洛尼白血病病毒敏感性的遗传控制。VI. 病毒特异性辅助性T细胞与B细胞协作的参与情况。
Eur J Immunol. 1982 Aug;12(8):692-7. doi: 10.1002/eji.1830120813.
10
A time study of the requirement for carrier-specific helper cells in the response of mice to dinitrophenylated keyhole limpet hemocyanin.关于小鼠对二硝基苯基化钥孔戚血蓝蛋白反应中载体特异性辅助性T细胞需求的时间研究。
Eur J Immunol. 1978 Aug;8(8):568-72. doi: 10.1002/eji.1830080806.

引用本文的文献

1
Production of antigen-specific suppressive T cell factor by radiation leukemia virus-transformed suppressor T cells.辐射白血病病毒转化的抑制性T细胞产生抗原特异性抑制性T细胞因子。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3804-8. doi: 10.1073/pnas.78.6.3804.
2
T cell clones: their use for the study of specificity, induction, and effector-function of T cells.T细胞克隆：它们在T细胞特异性、诱导及效应功能研究中的应用。
Springer Semin Immunopathol. 1980 May;3(1):23-37. doi: 10.1007/BF00199924.
3
Acetylcholine receptor-specific suppressive T-cell factor from a retrovirally transformed T-cell line.来自逆转录病毒转化的T细胞系的乙酰胆碱受体特异性抑制性T细胞因子。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7569-73. doi: 10.1073/pnas.81.23.7569.
4
T-cell clones and T-cell receptors.T细胞克隆与T细胞受体。
Microbiol Rev. 1986 Mar;50(1):50-69. doi: 10.1128/mr.50.1.50-69.1986.

本文引用的文献

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POTENTIATION OF VIRUS LEUKAEMOGENESIS IN C57BL MICE BY X-IRRADIATION OR URETHANE.X射线照射或氨基甲酸乙酯对C57BL小鼠病毒白血病发生的增强作用
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Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice.小鼠辐射诱导淋巴肿瘤滤液的致白血病活性。
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A simple micro cytotoxicity test.一种简单的微量细胞毒性试验。
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Fine structural alterations of interphase nuclei of lymphocytes stimulated to grwoth activity in vitro.体外刺激生长活性的淋巴细胞间期核的超微结构改变。
J Cell Biol. 1968 Dec;39(3):630-60. doi: 10.1083/jcb.39.3.630.
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Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
Immunology. 1968 Apr;14(4):599-600.
6
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
7
Cell-to-cell interaction in the immune response. VI. Contribution of thymus-derived cells and antibody-forming cell precursors to immunological memory.免疫反应中的细胞间相互作用。VI. 胸腺衍生细胞和抗体形成细胞前体对免疫记忆的作用。
J Exp Med. 1971 Jul 1;134(1):66-82. doi: 10.1084/jem.134.1.66.
8
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
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9
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.胸腺来源淋巴细胞上Ia（与H-2相关）抗原表达的证据。
J Exp Med. 1974 Nov 1;140(5):1273-84. doi: 10.1084/jem.140.5.1273.
10
Antigen binding T and B lymphocytes. I. Differences in cellular specificity and influence of metabolic activity on interaction of antigen with T and B cells.抗原结合性T淋巴细胞和B淋巴细胞。I. 细胞特异性差异以及代谢活性对抗原与T细胞和B细胞相互作用的影响。
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功能性、抗原特异性、载体致敏小鼠T细胞淋巴瘤的诱导、体外建立及特性分析

Induction, establishment in vitro, and characterization of functional, antigen-specific, carrier-primed murine T-cell lymphomas.

作者信息

Finn O J, Boniver J, Kaplan H S

出版信息

Proc Natl Acad Sci U S A. 1979 Aug;76(8):4033-7. doi: 10.1073/pnas.76.8.4033.

DOI:10.1073/pnas.76.8.4033
PMID:91171
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC383971/
Abstract

T cells were isolated from spleens of C57BL/Ka/Thy 1.1/Lb mice immunized with 2,4-dinitrophenylated keyhole limpet hemocyanin (DNP-KLH). The mice were infected in vitro with radiation leukemia virus and injected intrathymically into congenic C57BL/Ka (Thy 1.2) recipients. Within 3-4 months, seven thymic lymphomas developed, five of which were of donor type. The donor lymphomas were explanted and permanent cell lines were established in vitro. These lymphoma cells are capable of providing antigen-specific carrier (KLH)-primed help to DNP-primed B lymphocytes in secondary antibody production to DNP-KLH. They also enhance the secondary antibody response of whole period spleen cell populations to DNP-KLH. The availability of these immortal clonable populations of immunofunctional neoplastic T lymphocytes should facilitate biological and biochemical investigations of lymphocyte interactions during synthesis of antibody to thymus-dependent antigens.

摘要

从用2,4 - 二硝基苯基化钥孔戚血蓝蛋白（DNP - KLH）免疫的C57BL/Ka/Thy 1.1/Lb小鼠的脾脏中分离出T细胞。这些小鼠在体外感染辐射白血病病毒，然后胸腺内注射到同基因的C57BL/Ka（Thy 1.2）受体小鼠体内。在3 - 4个月内，出现了7个胸腺淋巴瘤，其中5个是供体类型。将供体淋巴瘤取出并在体外建立了永久细胞系。这些淋巴瘤细胞能够在针对DNP - KLH的二次抗体产生中，为经DNP致敏的B淋巴细胞提供抗原特异性载体（KLH）引发的辅助。它们还增强了整个脾细胞群体对DNP - KLH的二次抗体反应。这些具有免疫功能的肿瘤性T淋巴细胞的永生可克隆群体的获得，应有助于对胸腺依赖性抗原抗体合成过程中淋巴细胞相互作用进行生物学和生物化学研究。