Lebaron R G
Division of Life Sciences, Cell and Molecular Biology, University of Texas at San Antonio 78249, USA.
Perspect Dev Neurobiol. 1996;3(4):261-71.
Proteoglycans have long been recognized as participating in a number of biological activities ranging from structural roles to regulation of transcription. Versican is a large chondroitin sulfate proteoglycan expressed in several tissues, including the nervous system. Significant progress has been made in the understanding of the molecular structure and biological activity of versican. The progress is largely due to the application of recombinant DNA methodology and the generation of domain-specific anti-versican antibodies. In the central and peripheral nervous system, versican is expressed by glial cells and is implicated in the regulation of cell adhesion, migration, pattern formation, and regeneration.
蛋白聚糖长期以来被认为参与了从结构作用到转录调控等多种生物活动。多功能蛋白聚糖是一种在包括神经系统在内的多种组织中表达的大型硫酸软骨素蛋白聚糖。在对多功能蛋白聚糖的分子结构和生物活性的理解方面已经取得了重大进展。这一进展很大程度上归功于重组DNA方法的应用以及结构域特异性抗多功能蛋白聚糖抗体的产生。在中枢和外周神经系统中，多功能蛋白聚糖由神经胶质细胞表达，并参与细胞黏附、迁移、模式形成和再生的调控。
