亲本GAT-巨噬细胞刺激的（反应者X无反应者）F1脾细胞对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的体外二次抗体反应。
Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages.
作者信息
Pierce C W, Germain R N, Kapp J A, Benacerraf B
出版信息
J Exp Med. 1977 Dec 1;146(6):1827-32. doi: 10.1084/jem.146.6.1827.
Abstract
The development of IgG L-glutamic Acid60-L-alanine30-L-tyrosine10 (GAT)-specific plaque-forming cell responses in vitro by virgin and immune (responder X nonresponder)F1 spleen cells after stimulation with responder and nonresponder parental GAT-macrophages (Mphi) was investigated. Virgin F1 spleen cells developed comparable primary responses to both parental GAT-Mphi. By contrast, F1 spleen cells from mice immunized with GAT or responder parental GAT-Mphi developed secondary responses after stimulation with only responder parental GAT-Mphi. Spleen cells from F1 mice immunized with nonresponder parental GAT-Mphi developed secondary responses to these GAT-Mphi, but failed to respond to responder parental GAT-Mphi. These results are discussed in the context of genetic restrictions regulating Mphi-T-cell interactions in secondary antibody responses and the possible expression of Ir-gene function in Mphi.
摘要
研究了经应答者和非应答者亲本谷氨酸-丙氨酸-酪氨酸（GAT）-巨噬细胞（Mphi）刺激后，未致敏和免疫（应答者×非应答者）F1脾细胞在体外产生IgG L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）特异性空斑形成细胞反应的情况。未致敏的F1脾细胞对两种亲本GAT-Mphi产生了相当的 primary反应。相比之下，用GAT或应答者亲本GAT-Mphi免疫的小鼠的F1脾细胞，仅在应答者亲本GAT-Mphi刺激后产生secondary反应。用非应答者亲本GAT-Mphi免疫的F1小鼠的脾细胞对这些GAT-Mphi产生secondary反应，但对应答者亲本GAT-Mphi无反应。在调节secondary抗体反应中Mphi-T细胞相互作用的遗传限制以及Mphi中Ir基因功能的可能表达的背景下讨论了这些结果。 （注：文中primary和secondary未找到准确对应中文术语，暂保留英文）
相似文献
1
Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages.亲本GAT-巨噬细胞刺激的（反应者X无反应者）F1脾细胞对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的体外二次抗体反应。
J Exp Med. 1977 Dec 1;146(6):1827-32. doi: 10.1084/jem.146.6.1827.
2
Suppressor T-cell activity in responder X nonresponder (C57BL/10 X DBA/1)F1 spleen cells responsive to L-glutamic acid60-L-alanine30-L-tyrosine10.对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10有反应的反应者X无反应者（C57BL/10×DBA/1）F1脾细胞中的抑制性T细胞活性
J Exp Med. 1978 Nov 1;148(5):1282-91. doi: 10.1084/jem.148.5.1282.
3
The involvement of suppressor T cells in Ir gene regulation of secondary antibody responses of primed (responder X nonresponder)F1 mice to macrophage-bound L-glutamic acid60-L-alanine30-L-tyrosine.抑制性T细胞参与致敏（反应者×无反应者）F1小鼠对巨噬细胞结合的L-谷氨酸60-L-丙氨酸30-L-酪氨酸二次抗体反应的Ir基因调控。
J Exp Med. 1978 Nov 1;148(5):1324-37. doi: 10.1084/jem.148.5.1324.
4
5
Antigen-specific suppressor T-cell activity in genetically restricted immune spleen cells.基因受限免疫脾细胞中的抗原特异性抑制性T细胞活性。
J Exp Med. 1978 Nov 1;148(5):1271-81. doi: 10.1084/jem.148.5.1271.
6
7
8
Antigen-specific suppression in genetic responder mice to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). Characterization of conventional and hybridoma-derived factors produced by suppressor T cells from mice injected as neonates with syngeneic GAT macrophages.对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的基因反应性小鼠中的抗原特异性抑制。对新生期注射同基因GAT巨噬细胞的小鼠的抑制性T细胞产生的传统因子和杂交瘤衍生因子的特性研究。
J Exp Med. 1982 Dec 1;156(6):1691-710. doi: 10.1084/jem.156.6.1691.
9
Genetic control of immune responses in vitro. II. Cellular requirements for the development of primary plaque-forming cell responses to the random terpolymer 1-glutamic acid 60-1-alanine30-1-tyrosine10 (GAT) by mouse spleen cells in vitro.体外免疫反应的遗传控制。II. 小鼠脾细胞在体外对随机三聚物1-谷氨酸60-1-丙氨酸30-1-酪氨酸10（GAT）产生原发性噬斑形成细胞反应的细胞条件。
J Exp Med. 1973 Nov 1;138(5):1121-32. doi: 10.1084/jem.138.5.1121.
10
L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT): A probe for regulatory mechanisms in antibody responses.L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）：一种用于抗体应答调节机制的探针。
Adv Exp Med Biol. 1978;98:419-28. doi: 10.1007/978-1-4615-8858-0_24.
引用本文的文献
1
Normal HBsAg presentation and T-cell defect in the immune response of nonresponders.无应答者免疫反应中正常的乙肝表面抗原呈现及T细胞缺陷。
Immunogenetics. 1995;41(6):366-74. doi: 10.1007/BF00163994.
2
Immune response genes control T killer cell response against Moloney tumor antigen cytolysis regulating reactions against the best available H-2 + viral antigen association.免疫反应基因控制T杀伤细胞对莫洛尼肿瘤抗原的细胞溶解反应，调节针对最佳可用H-2+病毒抗原关联的反应。
J Exp Med. 1980 Jun 1;151(6):1468-76. doi: 10.1084/jem.151.6.1468.
3
Antigen-reactive T clones. III. Low responder antigen-presenting cells function effectively to present antigen to selected T cell clones derived from (High Responder x Low Responder)F1 mice.抗原反应性T克隆。III.低反应性抗原呈递细胞能有效地将抗原呈递给源自（高反应性×低反应性）F1小鼠的选定T细胞克隆。
J Exp Med. 1981 Sep 1;154(3):883-91. doi: 10.1084/jem.154.3.883.
4
Function of macrophages as antigen presenting cells.巨噬细胞作为抗原呈递细胞的功能。
Springer Semin Immunopathol. 1980 Aug;3(2):247-64. doi: 10.1007/BF02053977.
5
Antigen-specific T lymphocyte clones. II. Purification and biological characterization of an antigen-specific suppressive protein synthesized by cloned T cells.抗原特异性T淋巴细胞克隆。II. 克隆T细胞合成的抗原特异性抑制蛋白的纯化及生物学特性
J Exp Med. 1981 May 1;153(5):1260-74. doi: 10.1084/jem.153.5.1260.
6
The role of H-2-linked genes in helper T cell function. VII. Expression of I region and immune response genes by B cells in bystander help assays.H-2 连锁基因在辅助性 T 细胞功能中的作用。VII. 在旁观者辅助测定中 B 细胞对 I 区基因和免疫反应基因的表达。
J Exp Med. 1980 Nov 1;152(5):1274-88. doi: 10.1084/jem.152.5.1274.
7
The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.H-2连锁基因在辅助性T细胞功能中的作用。IV. T细胞基因型和宿主环境在I区及Ir基因表达中的重要性。
J Exp Med. 1978 Dec 1;148(6):1510-22. doi: 10.1084/jem.148.6.1510.
8
The involvement of suppressor T cells in Ir gene regulation of secondary antibody responses of primed (responder X nonresponder)F1 mice to macrophage-bound L-glutamic acid60-L-alanine30-L-tyrosine.抑制性T细胞参与致敏（反应者×无反应者）F1小鼠对巨噬细胞结合的L-谷氨酸60-L-丙氨酸30-L-酪氨酸二次抗体反应的Ir基因调控。
J Exp Med. 1978 Nov 1;148(5):1324-37. doi: 10.1084/jem.148.5.1324.
9
Suppressor T-cell activity in responder X nonresponder (C57BL/10 X DBA/1)F1 spleen cells responsive to L-glutamic acid60-L-alanine30-L-tyrosine10.对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10有反应的反应者X无反应者（C57BL/10×DBA/1）F1脾细胞中的抑制性T细胞活性
J Exp Med. 1978 Nov 1;148(5):1282-91. doi: 10.1084/jem.148.5.1282.
10
Antigen-specific suppressor T-cell activity in genetically restricted immune spleen cells.基因受限免疫脾细胞中的抗原特异性抑制性T细胞活性。
J Exp Med. 1978 Nov 1;148(5):1271-81. doi: 10.1084/jem.148.5.1271.
本文引用的文献
1
Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.豚鼠T淋巴细胞抗原识别中巨噬细胞的作用。I. 对组织相容性巨噬细胞和淋巴细胞的需求。
J Exp Med. 1973 Nov 1;138(5):1194-212. doi: 10.1084/jem.138.5.1194.
2
The regulatory role of macrophages in antigenic stimulation.巨噬细胞在抗原刺激中的调节作用。
Adv Immunol. 1972;15:95-165. doi: 10.1016/s0065-2776(08)60684-7.
3
Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT).体外免疫反应的遗传控制。V. 三元共聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）对无反应小鼠中抑制性T细胞的刺激
J Exp Med. 1974 Sep 1;140(3):648-59. doi: 10.1084/jem.140.3.648.
4
Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.豚鼠T淋巴细胞抗原识别中巨噬细胞的功能。II. 巨噬细胞在免疫反应基因控制调节中的作用。
J Exp Med. 1973 Nov 1;138(5):1213-29. doi: 10.1084/jem.138.5.1213.
5
Genetic control of immune responses in vitro. II. Cellular requirements for the development of primary plaque-forming cell responses to the random terpolymer 1-glutamic acid 60-1-alanine30-1-tyrosine10 (GAT) by mouse spleen cells in vitro.体外免疫反应的遗传控制。II. 小鼠脾细胞在体外对随机三聚物1-谷氨酸60-1-丙氨酸30-1-酪氨酸10（GAT）产生原发性噬斑形成细胞反应的细胞条件。
J Exp Med. 1973 Nov 1;138(5):1121-32. doi: 10.1084/jem.138.5.1121.
6
Genetic control of immune responses in vitro. I. Development of primary and secondary plaque-forming cell responses to the random terpolymer 1-glutamic acid 60-1-alanine30-1-tyrosine10 (GAT) by mouse spleen cells in vitro.体外免疫反应的遗传控制。I. 小鼠脾细胞在体外对随机三元共聚物1-谷氨酸60-1-丙氨酸30-1-酪氨酸10（GAT）的初次和二次噬斑形成细胞反应的发展。
J Exp Med. 1973 Nov 1;138(5):1107-20. doi: 10.1084/jem.138.5.1107.
7
Role of major histocompatibility complex gene products in delayed-type hypersensitivity.主要组织相容性复合体基因产物在迟发型超敏反应中的作用。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2486-90. doi: 10.1073/pnas.73.7.2486.
8
Genetic control of immune responses in vitro. VI. Experimental conditions for the development of helper T-cell activity specific for the terpolymer L-glutamic aicd60-L-alanine30-L-tyrosine10 (GAT) in nonresponder mice.体外免疫反应的遗传控制。VI. 无反应小鼠中针对三元共聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的辅助性T细胞活性发育的实验条件。
J Exp Med. 1975 Jul 1;142(1):50-60. doi: 10.1084/jem.142.1.50.
9
The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.巨噬细胞在辅助性T细胞生成中的作用。II. 巨噬细胞与T细胞相互作用以通过可溶性抗原诱导辅助性细胞的遗传控制。
J Exp Med. 1975 Aug 1;142(2):460-72. doi: 10.1084/jem.142.2.460.
10
Regulation by the H-2 gene complex of macrophage-lymphoid cell interactions in secondary antibody responses in vitro.体外二次抗体应答中巨噬细胞-淋巴细胞相互作用的H-2基因复合体调控
J Exp Med. 1976 Aug 1;144(2):371-81. doi: 10.1084/jem.144.2.371.
Zotero 插件