Jalava M, Sillanpää M
Department of Child Neurology, University of Turku, Finland.
Epilepsia. 1997 Apr;38(4):424-9. doi: 10.1111/j.1528-1157.1997.tb01731.x.
To show any possible associations between childhood-onset epilepsy and physical activity, health-related fitness, and health experience.
A population-based cohort of 176 patients with epilepsy since childhood was monitored for a mean of 35 years. Patients with recurrent, unprovoked epileptic seizures with no associated initial neurologic impairment or disability, termed those with "epilepsy only" (n = 100), were compared with matched controls for self-reported physical activity, health experience, laboratory tests, body mass index, and muscle power tests.
On the basis of muscle tests, physical fitness proved to be significantly poorer in patients with "epilepsy only" than in matched controls. During the preceding year, 22% of patients and 24% of controls had reduced their physical activities because of some illness; only 2% reduced their physical activities because of epilepsy. No significant difference was found in blood status, except for a lower serum creatinine level in the patients. Current antiepileptic drug (AED) therapy appeared significantly associated with lower hemoglobin and creatinine levels and higher high-density lipoprotein values. The patients perceived their health status to be comparable with that of controls, irrespective of physical inactivity, continued seizures, or AED monotherapy. However, patients receiving AED polytherapy perceived their health as rather poor or very poor significantly more often than did controls.
Based on objective muscle tests, adults with childhood-onset "epilepsy only" have poorer physical fitness than do matched controls, but they have a feeling of good personal health.
探究儿童期起病的癫痫与身体活动、健康相关体能及健康体验之间的潜在关联。
对176例自儿童期起病的癫痫患者进行基于人群的队列研究，平均监测35年。将那些有复发性、无端癫痫发作且无相关初始神经功能损害或残疾的患者，即“仅患有癫痫”的患者（n = 100），与匹配的对照组在自我报告的身体活动、健康体验、实验室检查、体重指数和肌肉力量测试方面进行比较。
基于肌肉测试，“仅患有癫痫”的患者体能明显比匹配的对照组差。在前一年，22%的患者和24%的对照组因某种疾病减少了身体活动；只有2%因癫痫减少了身体活动。除患者血清肌酐水平较低外，血液状况未发现显著差异。目前的抗癫痫药物（AED）治疗似乎与较低的血红蛋白和肌酐水平以及较高的高密度脂蛋白值显著相关。患者认为他们的健康状况与对照组相当，无论是否缺乏身体活动、癫痫持续发作或接受AED单药治疗。然而，接受AED联合治疗的患者比对照组更频繁地认为自己的健康状况相当差或非常差。
基于客观的肌肉测试，儿童期起病的“仅患有癫痫”的成年人比匹配的对照组体能更差，但他们自我感觉健康状况良好。
