Fukao A, Tsubono Y, Kawamura M, Ido T, Akazawa N, Tsuji I, Komatsu S, Minami Y, Hisamichi S
Department of Public Health, Tohoku University School of Medicine, Japan.
Int J Epidemiol. 1996 Apr;25(2):300-6. doi: 10.1093/ije/25.2.300.
Previous studies indicated that serum beta-carotene levels were low among smokers and drinkers. However these findings may result from the strong relationship between smoking and drinking.
Data were collected from 1902 males randomly selected from participants of a cohort study. The effects of smoking on serum beta-carotene levels were assessed according to drinking status (non-drinker, ex-drinker and current drinker), and those of drinking were assessed according to smoking status (ex-smoker and current smoker) using general linear model including other factors (age, intake of green-yellow vegetables, intake of carrot or pumpkin, body mass index serum cholesterol levels.)
An inverse dose-response relationship between daily consumption of alcohol and beta-carotene levels was observed regardless of smoking status, and also between number of cigarettes smoked per day and beta-carotene levels regardless of drinking status.
These results suggest that cigarette smoking and alcohol drinking reduce beta-carotene levels independently.
先前的研究表明,吸烟者和饮酒者的血清β-胡萝卜素水平较低。然而,这些发现可能源于吸烟与饮酒之间的紧密关系。
从一项队列研究的参与者中随机选取1902名男性收集数据。根据饮酒状况(不饮酒者、既往饮酒者和当前饮酒者)评估吸烟对血清β-胡萝卜素水平的影响,根据吸烟状况(既往吸烟者和当前吸烟者)评估饮酒对血清β-胡萝卜素水平的影响,使用包含其他因素(年龄、黄绿色蔬菜摄入量、胡萝卜或南瓜摄入量、体重指数、血清胆固醇水平)的一般线性模型。
无论吸烟状况如何,每日酒精摄入量与β-胡萝卜素水平之间均观察到剂量反应负相关关系;无论饮酒状况如何,每日吸烟量与β-胡萝卜素水平之间也存在剂量反应负相关关系。
这些结果表明,吸烟和饮酒会独立降低β-胡萝卜素水平。