Wallström P, Wirfält E, Lahmann P H, Gullberg B, Janzon L, Berglund G
Department of Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.
Am J Clin Nutr. 2001 Apr;73(4):777-85. doi: 10.1093/ajcn/73.4.777.
Previous studies of associations between diet, obesity, and blood concentrations of alpha-tocopherol and beta-carotene have been equivocal. Furthermore, most studies used only body mass index (BMI) as an obesity measure.
Our objectives were to examine the associations between energy and nutrient intakes, alcohol consumption, tobacco use, and serum cholesterol and serum concentrations of alpha-tocopherol and beta-carotene, and to examine the associations between different measures of general and central adiposity and serum concentrations of alpha-tocopherol and beta-carotene.
This was a cross-sectional, population-based study of 253 men and 276 women aged 46-67 y. Nutrient data were collected by a modified diet history method. Measures of obesity included BMI, percentage of body fat (impedance analysis), waist-to-hip ratio, and waist circumference. The associations between serum nutrient concentrations and the other factors were examined by multiple linear regression.
Twenty-one percent of men and 34% of women used antioxidant supplements. The mean BMI was 26.1 in men and 25.4 in women. Serum beta-carotene concentration was positively associated with serum cholesterol concentration, fiber intake, and beta-carotene intake, and negatively associated with smoking and all measures of obesity. In men, serum beta-carotene concentration was not significantly associated with central adiposity after adjustment for body fat. Serum alpha-tocopherol concentration was positively correlated with serum cholesterol, obesity, and vitamin E intake. In women, serum alpha-tocopherol concentration was also positively associated with intakes of ascorbic acid and selenium. Serum alpha-tocopherol concentration was associated with central adiposity after adjustment for body fat.
Serum beta-carotene and alpha-tocopherol concentrations have different associations with diet, smoking, general adiposity, and central adiposity.
先前关于饮食、肥胖与α-生育酚和β-胡萝卜素血液浓度之间关联的研究结果并不明确。此外，大多数研究仅将体重指数（BMI）作为肥胖的衡量指标。
我们的目的是研究能量和营养素摄入量、饮酒、吸烟与血清胆固醇以及α-生育酚和β-胡萝卜素血清浓度之间的关联，并研究一般肥胖和中心性肥胖的不同测量指标与α-生育酚和β-胡萝卜素血清浓度之间的关联。
这是一项基于人群的横断面研究，研究对象为253名年龄在46 - 67岁的男性和276名女性。通过改良的饮食史方法收集营养数据。肥胖测量指标包括BMI、体脂百分比（阻抗分析）、腰臀比和腰围。通过多元线性回归研究血清营养素浓度与其他因素之间的关联。
21%的男性和34%的女性使用抗氧化剂补充剂。男性的平均BMI为26.1，女性为25.4。血清β-胡萝卜素浓度与血清胆固醇浓度、纤维摄入量和β-胡萝卜素摄入量呈正相关，与吸烟和所有肥胖测量指标呈负相关。在男性中，调整体脂后，血清β-胡萝卜素浓度与中心性肥胖无显著关联。血清α-生育酚浓度与血清胆固醇、肥胖和维生素E摄入量呈正相关。在女性中，血清α-生育酚浓度也与抗坏血酸和硒的摄入量呈正相关。调整体脂后，血清α-生育酚浓度与中心性肥胖有关。
血清β-胡萝卜素和α-生育酚浓度与饮食、吸烟、一般肥胖和中心性肥胖有不同的关联。
