Navarro J F, Mora C, Marcén R, Teruel J L, Gámez C, Jiménez J J, Orofino L, Ortuño J
Department of Nephrology, Hospital Ntra. Sra. de Candelaria, Santa Cruz de Tenerife, Canary Islands.
Int Urol Nephrol. 1996;28(4):575-81. doi: 10.1007/BF02550970.
The acute effects of intravenous (i.v.) cyclosporine A (CsA) on blood pressure and other haemodynamic parameters were examined in 8 patients with end-stage renal disease on haemodialysis (HD). The study was performed after the mid-week haemodialysis session, when the patients were on their dry body weight. Each patient received an i.v. infusion of 5 mg/kg of CsA in 120 ml of 5% dextrose in water during 2 hours. Heart rate, systolic and diastolic blood pressure (SBP, DBP) were monitored by the Holter system. An echocardiogram (M-mode 2-dimensional and Doppler sonography) was performed using an automatic device (Ultramark 6) before CsA administration, at 30, 60 and 120 minutes during CsA infusion, and at 30 minutes thereafter. SBP, DBP and calculated peripheral vascular resistance (CPVR) increased significantly in respect to basal values at 120 and 150 minutes (SBP: basal 130 +/- 21, 120 min: 136 +/- 20, 150 min: 140 +/- 18, p < 0.05 and p < 0.01, respectively. DBP: basal 80 +/- 9, 120 min: 86 +/- 13, 150 min: 88 +/- 13, p < 0.05 and p < 0.01, respectively. CPVR: basal 1000 +/- 228, 120 min: 1178 +/- 305, 150 min: 1236 +/- 270 dyne/s/cm5, p < 0.01). However, systolic volume (SV) and cardiac output (CO) showed significant decreases from the basal values (SV: basal 103 +/- 29, 120 min: 85 +/- 22, 150 min: 85 +/- 17, p < 0.05. CO: basal 8.2 +/- 2, 120 min: 7.3 +/- 1.1, 150 min: 7 +/- 1.2 l/min, p < 0.05). In conclusion, CsA infusion produces a significant elevation of blood pressure, which seems to be mediated by a direct action on peripheral vascular resistance.
在8例接受血液透析（HD）的终末期肾病患者中，研究了静脉注射环孢素A（CsA）对血压和其他血流动力学参数的急性影响。该研究在周中血液透析 session 之后进行，此时患者处于干体重状态。每位患者在2小时内接受了在120 ml 5%葡萄糖水溶液中静脉输注5 mg/kg的CsA。通过动态心电图系统监测心率、收缩压和舒张压（SBP、DBP）。在给予CsA之前、CsA输注期间的30、60和120分钟以及之后的30分钟，使用自动设备（Ultramark 6）进行超声心动图检查（M型二维和多普勒超声）。SBP、DBP和计算得出的外周血管阻力（CPVR）在120和150分钟时相对于基础值显著增加（SBP：基础值130±21，120分钟：136±20，150分钟：140±18，p分别<0.05和<0.01。DBP：基础值80±9，120分钟：86±13，150分钟：88±13，p分别<0.05和<0.01。CPVR：基础值1000±228，120分钟：1178±305，150分钟：1236±270达因/秒/厘米5，p<0.01）。然而，每搏量（SV）和心输出量（CO）相对于基础值显著降低（SV：基础值103±29，120分钟：85±22，150分钟：85±17，p<0.05。CO：基础值8.2±2，120分钟：7.3±1.1，150分钟：7±1.2升/分钟，p<0.05）。总之，输注CsA会导致血压显著升高，这似乎是由对外周血管阻力的直接作用介导的。
