Barnstable C J, Snary D, Crumpton M J, Bodmer W F
Tissue Antigens. 1979 May;13(5):334-41. doi: 10.1111/j.1399-0039.1979.tb00805.x.
The HLA--Bw4 and Bw6 antigenic determinants have been shown to co-migrate with HLA--B determinants on gel-filtration, sucrose density gradient centrifugation and affinity chromatography, using Lens culinaris lectin and antibody against human beta 2 microbulin. These and other published data imply that the HLA--Bw4 and Bw6 determinants reside on the same polypeptide chain as other HLA--B locus determinants. The implications of this in terms of the evolution of cross reacting groups of antigens at the HLA--B locus are discussed.
使用菜豆凝集素和抗人β2微球蛋白抗体，在凝胶过滤、蔗糖密度梯度离心和亲和层析中，已表明HLA - Bw4和Bw6抗原决定簇与HLA - B决定簇共同迁移。这些以及其他已发表的数据表明，HLA - Bw4和Bw6决定簇与其他HLA - B位点决定簇位于同一条多肽链上。本文讨论了这一点对HLA - B位点抗原交叉反应组进化的影响。
