Gunn I, Leheny W, Lakshmipathi T, Lamont M A, Faed M
Tissue Antigens. 1979 Aug;14(2):157-64. doi: 10.1111/j.1399-0039.1979.tb00833.x.
Sixty-one patients in the Dundee area suffering from psoriasis were typed for HLA-A and HLA-B antigens. On the basis of the typing results, the patients were divided into three groups, and studied with respect to sex, age of onset and familial incidence of the disease. The frequency of HLA-A1 appeared to be increased and HLA-B7 decreased but HLA-B13 and HLA-B17 were highly significantly increased (P less than 10(-6) and P less than 10(-10) respectively) in the psoriatic group compared to 204 controls. Of particular interest was a highly significant association of HLA-A1 with HLA-B17 in psoriatic patients. Family studies showed HLA-B17 to be a useful genetic marker for psoriasis in the families of B17 positive patients. Considerations of age of onset, familial incidence and typing data suggest that there is heterogeneity of genetic susceptibility to psoriasis and that one probable mechanism is the dominant inheritance of a "disease allele" in linkage disequilibrium with the allele coding for HLA-B17.
对邓迪地区61名银屑病患者进行了HLA - A和HLA - B抗原分型。根据分型结果，将患者分为三组，并就性别、发病年龄和疾病家族发病率进行了研究。与204名对照相比，银屑病组中HLA - A1频率似乎增加而HLA - B7频率降低，但HLA - B13和HLA - B17显著增加（分别为P < 10^(-6)和P < 10^(-10)）。特别值得关注的是，银屑病患者中HLA - A1与HLA - B17存在高度显著关联。家族研究表明，HLA - B17是B17阳性患者家族中银屑病的一个有用的遗传标记。对发病年龄、家族发病率和分型数据的考量表明，银屑病的遗传易感性存在异质性，一种可能的机制是与编码HLA - B17的等位基因处于连锁不平衡状态的“疾病等位基因”的显性遗传。
