Ridet J L, Privat A
INSERM U. 336, University Montpellier II, France.
J Neurosci Res. 1995 Oct 15;42(3):287-93. doi: 10.1002/jnr.490420302.
Over the last decade, the combination of molecular biology and cell transplantation techniques has given rise to a powerful method for gene therapy. The implantation of genetically modified cultured cells has been extensively used in the central nervous system (CNS) in various experimental models of neurologic disorders. More recently, viral and chemical methods have been developed to further efforts to shuttle transgenes into the relatively inaccessible brain. Adenoviral and liposomal synthetic vectors carry transgenes into neural tissue in situ and are beginning to show promise as new methods for CNS therapy.
在过去十年中，分子生物学与细胞移植技术的结合催生了一种强大的基因治疗方法。基因修饰培养细胞的植入已在各种神经系统疾病的实验模型中广泛应用于中枢神经系统（CNS）。最近，已开发出病毒和化学方法，以进一步努力将转基因导入相对难以到达的大脑。腺病毒和脂质体合成载体将转基因原位导入神经组织，并开始显示出作为中枢神经系统治疗新方法的前景。
