加蓬不同疫情中埃博拉病毒的分离与系统发育特征分析
Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon.
作者信息
Georges-Courbot M C, Sanchez A, Lu C Y, Baize S, Leroy E, Lansout-Soukate J, Tévi-Bénissan C, Georges A J, Trappier S G, Zaki S R, Swanepoel R, Leman P A, Rollin P E, Peters C J, Nichol S T, Ksiazek T G
机构信息
Centre International de Recherches Médicales, Franceville, Gabon.
出版信息
Emerg Infect Dis. 1997 Jan-Mar;3(1):59-62. doi: 10.3201/eid0301.970107.
Abstract
Three outbreaks of Ebola hemorrhagic fever have recently occurred in Gabon. Virus has been isolated from clinical materials from all three outbreaks, and nucleotide sequence analysis of the glycoprotein gene of the isolates and virus present in clinical samples has been carried out. These data indicate that each of the three outbreaks should be considered an independent emergence of a different Ebola virus of the Zaire subtype. As in earlier Ebola virus outbreaks, no genetic variability was detected between virus samples taken during an individual outbreak.
摘要
加蓬最近发生了三起埃博拉出血热疫情。已从所有三起疫情的临床样本中分离出病毒，并对分离株和临床样本中存在的病毒的糖蛋白基因进行了核苷酸序列分析。这些数据表明，这三起疫情中的每一起都应被视为扎伊尔亚型不同埃博拉病毒的独立出现。与早期埃博拉病毒疫情一样，在单个疫情期间采集的病毒样本之间未检测到基因变异。
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