Kanai T, Fukuda-Miki M, Shimoya K, Azuma C, Hashimoto K, Nobunaga T, Tokugawa Y, Tsujimoto M, Saji F, Murata Y
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
Gynecol Obstet Invest. 1997;43(3):166-70. doi: 10.1159/000291847.
Interleukin-1 (IL-1) receptor antagonist (IL-1ra) levels in the cervical mucus of women in the ovulatory phase are significantly higher than those in the follicular phase. IL-1 titers of women in the ovulatory phase are also significantly higher than those in the follicular phase. A positive correlation between IL-1ra and IL-1 levels in the cervical mucus was observed. Immunohistochemistry using an anti-IL-1ra monoclonal antibody revealed positive staining in the epithelial cells of the endocervix. These results suggest that IL-1ra from cervical epithelial cells protects the reproductive system from the toxicity of IL-1 produced in the endocervix.
处于排卵期的女性宫颈黏液中白细胞介素-1（IL-1）受体拮抗剂（IL-1ra）水平显著高于卵泡期。处于排卵期的女性IL-1滴度也显著高于卵泡期。观察到宫颈黏液中IL-1ra与IL-1水平呈正相关。使用抗IL-1ra单克隆抗体的免疫组织化学显示宫颈内膜上皮细胞呈阳性染色。这些结果表明，来自宫颈上皮细胞的IL-1ra可保护生殖系统免受宫颈内膜产生的IL-1的毒性影响。
