Sakuma H, Saeed M, Takeda K, Wendland M F, Schwitter J, Szolar D H, Derugin N, Shimakawa A, Foo T K, Higgins C B
Department of Radiology, University of California, San Francisco 94143-0628, USA.
AJR Am J Roentgenol. 1997 May;168(5):1363-7. doi: 10.2214/ajr.168.5.9129446.
Breath-hold velocity-encoded cine (VENC) MR imaging has been proposed as a method for measuring coronary blood flow. However, most studies have measured velocity rather than volume flow rate in the coronary arteries. The purpose of this study was to measure volume flow rate in the coronary artery of dogs using high-speed gradients and to compare MR flow measurements with those obtained with a sonographic flowmeter.
Fast VENC MR images were obtained with a high-speed-gradient 1.5-T MR system in seven anesthetized dogs before and after administration of dipyridamole. Images were acquired on double oblique planes perpendicular to the left anterior descending arteries with a slice thickness of 5 mm, a field of view of 20 x 10 cm, a velocity window of +/- 1 m/sec, an average imaging time of 21 sec, a TR/TE of 11/5, and a temporal resolution of 44 msec.
Coronary flow measured with VENC MR imaging correlated well with flow measured by the flowmeter (r = .95, slope = 0.97, n = 88). Interobserver variability in measuring coronary flow volume was 8%.
Fast VENC MR imaging with high-speed gradients can provide accurate quantification of volume flow rate in coronary arteries.
屏气速度编码电影（VENC）磁共振成像已被提议作为一种测量冠状动脉血流的方法。然而，大多数研究测量的是冠状动脉中的速度而非容积流量。本研究的目的是使用高速梯度测量犬冠状动脉的容积流量，并将磁共振血流测量结果与超声流量计获得的结果进行比较。
在7只麻醉犬中，于给予双嘧达莫前后，使用高速梯度1.5-T磁共振系统获取快速VENC磁共振图像。在垂直于左前降支动脉的双斜面上采集图像，层厚5mm，视野20×10cm，速度窗口为±1m/秒，平均成像时间21秒，TR/TE为11/5，时间分辨率为44毫秒。
VENC磁共振成像测量的冠状动脉血流与流量计测量的血流相关性良好（r = 0.95，斜率 = 0.97，n = 88）。观察者间测量冠状动脉血流量的变异性为8%。
使用高速梯度的快速VENC磁共振成像能够准确量化冠状动脉的容积流量。
