Graf W D, Shepard T H
Department of Pediatrics, University of Washington School of Medicine, Seattle, USA.
J Child Neurol. 1997 Apr;12(3):225-7. doi: 10.1177/088307389701200315.
We report a patient with Möbius syndrome. The birth defect in this child is probably the result of both vasoconstriction and uterine contractions brought on by ergotamine taken during the sixth week of pregnancy. We propose that vasoconstrictive or mechanical effects, or both, of abortifacient drugs such as ergotamine and misoprostol may account for other cases of Möbius syndrome, and we suggest that uterine contraction from any cause, at about the sixth or seventh week of pregnancy, may cause this birth defect. Further observational studies are needed to verify this hypothesis.
我们报告了一名患有莫比乌斯综合征的患者。该患儿的出生缺陷可能是由于在怀孕第六周服用麦角胺引起的血管收缩和子宫收缩共同导致的。我们认为，麦角胺和米索前列醇等堕胎药物的血管收缩或机械作用，或两者兼而有之，可能是其他莫比乌斯综合征病例的病因，并且我们提出，怀孕约第六或第七周时，任何原因引起的子宫收缩都可能导致这种出生缺陷。需要进一步的观察性研究来验证这一假设。
