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Hirano小体与阿尔茨海默病。

Hirano bodies and Alzheimer's disease.

作者信息

Mitake S, Ojika K, Hirano A

机构信息

Department of Pathology, Montefiore Medical Center, Bronx, New York 10467-2490, USA.

出版信息

Kaohsiung J Med Sci. 1997 Jan;13(1):10-8.

PMID:9130818
Abstract

Hirano bodies are refractile eosinophilic rod-like structures, initially observed in Guamanian (Chamorro) patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex. Subsequent investigations revealed that Hirano bodies have a distinct topographic distribution in the hippocampus, and that their number increases in the pyramidal layer of Sommer's sector but not in the stratum lacunosum with advancing age. Since patients with Alzheimer's disease (AD) have significantly more Hirano bodies than normal subjects in the same age range, the inclusions appear seem to be of relevance in this disease. Immunohistochemical and electron microscopic studies have demonstrated that the main components of Hirano bodies are abnormal micro-filaments, and that not only molecules associated with cell cytoskeleton, but also some stress-related proteins and growth factors such as beta-amyloid precursor protein, hippocampal cholinergic neurostimulating peptide (HCNP), transforming growth factor beta 3 are present in Hirano bodies. The accumulation of HCNP in Hirano bodies suggests that patients bearing these inclusions may have a disturbance of the septohippocampal cholinergic system, considered to be of importance for le arning and memory formation, and hence be related to the memory impairment of AD.

摘要

Hirano小体是折光性嗜酸性棒状结构,最初在患有肌萎缩侧索硬化症和帕金森痴呆综合征的关岛(查莫罗)患者中观察到。随后的研究表明,Hirano小体在海马体中具有独特的地形分布,并且随着年龄的增长,其数量在 Sommer扇形区的锥体细胞层中增加,而在腔隙层中则不增加。由于阿尔茨海默病(AD)患者的Hirano小体比同年龄范围的正常受试者显著更多,这些包涵体似乎与这种疾病有关。免疫组织化学和电子显微镜研究表明,Hirano小体的主要成分是异常微丝,并且不仅与细胞骨架相关的分子,而且一些与应激相关的蛋白质和生长因子,如β-淀粉样前体蛋白、海马胆碱能神经刺激肽(HCNP)、转化生长因子β3也存在于Hirano小体中。HCNP在Hirano小体中的积累表明,带有这些包涵体的患者可能存在隔海马胆碱能系统紊乱,这被认为对学习和记忆形成很重要,因此与AD的记忆障碍有关。

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Hirano bodies and Alzheimer's disease.Hirano小体与阿尔茨海默病。
Kaohsiung J Med Sci. 1997 Jan;13(1):10-8.
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Possible implication of hippocampal cholinergic neurostimulating peptide (HCNP)-related components in Hirano body formation.海马胆碱能神经刺激肽(HCNP)相关成分在 Hirano 小体形成中的可能影响。
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Accumulation of hippocampal cholinergic neurostimulating peptide (HCNP)-related components in Hirano bodies.
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Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer's disease hippocampus.正常及阿尔茨海默病海马中平野体与神经丝蛋白共享表位的分析。
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The presence of FAC1 protein in Hirano bodies.海仁小体中FAC1蛋白的存在。
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Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease brains.泛素连接酶-1免疫反应性集中在阿尔茨海默病大脑中的 Hirano 小体和营养不良性神经突上。
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Advanced glycation endproducts are associated with Hirano bodies in Alzheimer's disease.晚期糖基化终产物与阿尔茨海默病中的 Hirano 小体有关。
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The association of actin with Hirano bodies.肌动蛋白与 Hirano 小体的关联。
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[The involvement of hippocampal cholinergic neurostimulating peptide and its precursor in Alzheimer pathogenesis].[海马胆碱能神经刺激肽及其前体在阿尔茨海默病发病机制中的作用]
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