Tamura M, Harada K, Ito T, Takahashi Y, Ishida A, Takada G
Department of Pediatrics, Akita University School of Medicine, Japan.
Early Hum Dev. 1997 Apr 25;48(1-2):1-9. doi: 10.1016/s0378-3782(96)01801-4.
To evaluate changes in the right ventricular volume in early human neonates, twenty fullterm infants were examined at 2, 24 and 120 h of age by two-dimensional echocardiography. End-diastolic and end-systolic right ventricular volumes (RVEDV and RVESV, respectively) were calculated with a computer system based on the bi-plane Simpson's rule using the apical four chamber and parasternal short axis views. Then right ventricular stroke volume (RVSV), ejection fraction (RVEF), and the mean normalized systolic ejection rate were obtained. The inner diameter of the ductus arteriosus was also measured simultaneously. RVEDV increased significantly by 24 h of age, but remained constant thereafter. RVESV remained virtually unchanged from 2 to 120 h, resulting in a significant increase (36%) of RVSV at 24 h compared with that at 2 h. The mean normalized systolic ejection rate remained unchanged. There was a good correlation between RVEDV and RVSV (r = 0.83). All ductus arteriosus except three narrow ones was closed by 24 h of age. In conclusion, at 24 h of age, the significantly increased RVEDV was closely related to the increased RVSV, which might be induced by increased volume load to the right ventricle because of the closure of the ductus arteriosus.
为评估早期人类新生儿右心室容积的变化，对20名足月儿在出生后2小时、24小时和120小时进行二维超声心动图检查。使用基于双平面辛普森法则的计算机系统，通过心尖四腔心切面和胸骨旁短轴切面计算舒张末期和收缩末期右心室容积（分别为RVEDV和RVESV）。然后得出右心室每搏输出量（RVSV）、射血分数（RVEF）以及平均标准化收缩期射血率。同时测量动脉导管内径。RVEDV在出生后24小时显著增加，但此后保持稳定。RVESV在2至120小时基本保持不变，导致24小时时RVSV相较于2小时时显著增加（36%）。平均标准化收缩期射血率保持不变。RVEDV与RVSV之间存在良好的相关性（r = 0.83）。除三根狭窄的动脉导管外，所有动脉导管在出生后24小时均已闭合。总之，在出生后24小时，显著增加的RVEDV与增加的RVSV密切相关，这可能是由于动脉导管闭合导致右心室容量负荷增加所致。
