Piecková E, Jesenská Z
Institute of Preventive and Clinical Medicine, Institute of Preventive and Clinical Medicine, Bratislava, Stovakia.
Folia Microbiol (Praha). 1996;41(6):517-20. doi: 10.1007/BF02814671.
The ciliostatic activity of exo- and endometabolites of 243 filamentous fungal strains was evaluated by in vitro bioassay using tracheal organ cultures of 1-d-old chicks. Chloroform-extractable metabolites produced in the cultivation medium (25 degrees C/10 d) by 30 out of 72 (41%) investigated strains displayed the ciliostatic activity as did metabolites from the biomass of the spores and the mycelium of 46 other strains (26%). This result could contribute to the clarification of the correlation between fungi and respiratory disorders in some working places and in damp dwellings.
使用1日龄雏鸡的气管器官培养物，通过体外生物测定法评估了243株丝状真菌菌株的外代谢产物和内代谢产物的纤毛抑制活性。在72株被研究菌株中，有30株（41%）在培养介质（25℃/10天）中产生的可被氯仿提取的代谢产物表现出纤毛抑制活性，另外46株菌株（26%）的孢子和菌丝体生物质中的代谢产物也表现出纤毛抑制活性。这一结果可能有助于阐明某些工作场所和潮湿住宅中真菌与呼吸系统疾病之间的关联。
