Monschau B, Kremoser C, Ohta K, Tanaka H, Kaneko T, Yamada T, Handwerker C, Hornberger M R, Löschinger J, Pasquale E B, Siever D A, Verderame M F, Müller B K, Bonhoeffer F, Drescher U
Department of Physical Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany.
EMBO J. 1997 Mar 17;16(6):1258-67. doi: 10.1093/emboj/16.6.1258.
Two ligands for Eph-related receptor tyrosine kinases, RAGS and ELF-1, have been implicated in the control of development of the retinotectal projection. Both molecules are expressed in overlapping gradients in the tectum, the target area of retinal ganglion cell axons. In two in vitro assays ELF-1 is shown to have a repellent axon guidance function for temporal, but apparently not for nasal axons. RAGS on the other hand is repellent for both types of axons, though to different degrees. Thus, RAGS and ELF-1 share some and differ in other properties. The biological activities of these molecules correlate with the strength of interaction with their receptors expressed on RGC axons. The meaning of these findings for guidance of retinal axons in the tectum is discussed.
两种与Eph相关的受体酪氨酸激酶的配体，RAGS和ELF-1，已被认为参与视网膜顶盖投射发育的调控。这两种分子在顶盖（视网膜神经节细胞轴突的靶区域）中以重叠梯度表达。在两项体外试验中，ELF-1对颞侧轴突具有排斥性轴突导向功能，但对鼻侧轴突显然没有。另一方面，RAGS对两种类型的轴突都有排斥作用，不过程度不同。因此，RAGS和ELF-1有一些共同特性，也有其他不同特性。这些分子的生物学活性与其与视网膜神经节细胞轴突上表达的受体的相互作用强度相关。本文讨论了这些发现对顶盖中视网膜轴突导向的意义。
