Edwards R, Beuter A
Département de Kinanthropologie, Université du Québec à Montréal, Canada.
Neurotoxicol Teratol. 1997 Mar-Apr;19(2):95-104. doi: 10.1016/s0892-0362(96)00179-1.
A portable, accelerometric system measuring tremor was evaluated. That is, the validity and consistency of measurements as well as its ability to discriminate pathologic from physiological tremor were investigated. Control subjects and patients with Parkinson's disease were tested with this portable system and with an independent system that gave precise displacement data using lasers. It was found that amplitude of postural tremor as measured by the two systems differed significantly, but further investigation revealed that this difference was due 1) to the difference between amplitude of acceleration and amplitude of displacement, and 2) to changes in tremor over the time between tests, rather than to any inaccuracy or unreliability in the portable system. The other characteristics of tremor reported by the portable system were also valid and reasonably reliable in test-retest experiments, with the exception of the "harmonic index," which proved less stable. Most of the reported characteristics were distributed differently for the control group and for the patients with Parkinson's disease, but the large overlaps between distributions would make diagnosis difficult when tremor is not very pronounced. These results suggest that until better discriminating measures of tremor are available, tremor tests should be repeated and combined with other tests of motor function.
对一个测量震颤的便携式加速度测量系统进行了评估。也就是说，研究了测量的有效性和一致性以及其区分病理性震颤和生理性震颤的能力。使用该便携式系统以及一个通过激光提供精确位移数据的独立系统对对照受试者和帕金森病患者进行了测试。结果发现，两个系统测量的姿势性震颤幅度存在显著差异，但进一步研究表明，这种差异是由于：1）加速度幅度和位移幅度之间的差异；2）测试之间震颤随时间的变化，而非便携式系统存在任何不准确或不可靠之处。在重测实验中，便携式系统报告的震颤的其他特征也是有效的且相当可靠的，但“谐波指数”除外，该指数被证明不太稳定。报告的大多数特征在对照组和帕金森病患者中的分布不同，但当震颤不太明显时，分布之间的大量重叠会使诊断变得困难。这些结果表明，在获得更好的震颤鉴别方法之前，应重复进行震颤测试并结合其他运动功能测试。
