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血管紧张素转换酶基因缺失多态性与海湾阿拉伯人群的高血压无关。

Deletion polymorphism in the angiotensin-converting enzyme gene is not associated with hypertension in a Gulf Arab population.

作者信息

Frossard P M, Obineche E N, Elshahat Y I, Lestringant G G

机构信息

Department of Pathology, Faculty of Medicine & Health Sciences, Al Ain, United Arab Emirates.

出版信息

Clin Genet. 1997 Mar;51(3):211-3. doi: 10.1111/j.1399-0004.1997.tb02455.x.

DOI:10.1111/j.1399-0004.1997.tb02455.x
PMID:9137889
Abstract

We have studied an insertion/deletion dimorphism in the human angiotensin-converting enzyme gene amongst UAE nationals from the Abu Dhabi Emirate. Our findings show lack of association between the I/D allele marker system and clinical diagnosis of essential hypertension, suggesting that variations of the angiotensin-converting enzyme gene do not play a major role in the determination of elevated blood pressure in this Arab population. This agrees with results reported on other ethnic groups.

摘要

我们研究了来自阿布扎比酋长国的阿联酋国民中人类血管紧张素转换酶基因的插入/缺失二态性。我们的研究结果表明，I/D等位基因标记系统与原发性高血压的临床诊断之间缺乏关联，这表明血管紧张素转换酶基因的变异在该阿拉伯人群血压升高的决定因素中不起主要作用。这与其他种族群体报道的结果一致。

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