Easton A J, Chambers P
Department of Biological Sciences, University of Warwick, Coventry, UK.
Virus Res. 1997 Apr;48(1):27-33. doi: 10.1016/s0168-1702(96)01430-x.
The nucleotide sequences of the genes encoding the matrix (M) protein and the small hydrophobic (SH) protein of pneumonia virus of mice (PVM) are described. The matrix protein gene contains a large open reading frame encoding polypeptide of 257 residues which shows considerable (38.6-42.1%) amino acid identity with the matrix proteins of other pneumoviruses. The matrix gene also contains a second, smaller, open reading frame (ORF) as seen with the equivalent genes of other pneumoviruses. The PVM second open reading frame is capable of encoding a polypeptide of 46 residues and shows no significant similarity with the proteins encoded by the equivalent open reading frames of the other pneumoviruses. The gene adjacent to that encoding the matrix protein encodes a small, 92 residue, polypeptide which has a central hydrophobic domain and is structurally similar to the small hydrophobic protein of respiratory syncytial virus.
描述了编码小鼠肺炎病毒（PVM）基质（M）蛋白和小疏水（SH）蛋白的基因的核苷酸序列。基质蛋白基因包含一个大的开放阅读框，编码257个残基的多肽，该多肽与其他肺病毒的基质蛋白显示出相当程度（38.6 - 42.1%）的氨基酸同一性。与其他肺病毒的等效基因一样，基质基因还包含第二个较小的开放阅读框（ORF）。PVM的第二个开放阅读框能够编码一个46个残基的多肽，与其他肺病毒等效开放阅读框所编码的蛋白质没有显著相似性。与编码基质蛋白的基因相邻的基因编码一个小的、92个残基的多肽，该多肽具有一个中央疏水结构域，并且在结构上与呼吸道合胞病毒的小疏水蛋白相似。
