Daniilidis M, Fountzilas G, Fleva A, Daniilidis J, Tourkantonis A
First Department of Internal Medicine, AHEPA Hospital, Aristotle University, Thessaloniki, Greece.
Oncology. 1997 May-Jun;54(3):185-92. doi: 10.1159/000227686.
The concept that the major histocompatibility complex (MHC) plays an important role in the pathogenesis of nasopharyngeal cancer (NPC) in several ethnic groups has gained increased attention during the last 15 years. Earlier studies have suggested that an increased risk of NPC is associated with specific phenotypes of human leukocyte antigens (HLA). The present study was performed to examine the association of HLA specificities and haplotypes with NPC in a Greek population. In a genotypical study of 53 patients, a significant association between the haplotype HLA-B5DR11 and NPC was found, mainly in patients > 45 years. Also, the above haplotype was significantly associated with longer disease-free interval. HLA-B5 and HLA-B5DR11 were more often seen among patients with squamous cell histology than among those with the undifferentiated type. These results suggest that MHC loci are probably implicated in the pathogenesis and outcome of NPC in Greek patients.
在过去15年里，主要组织相容性复合体（MHC）在多个种族的鼻咽癌（NPC）发病机制中起重要作用这一概念受到了越来越多的关注。早期研究表明，NPC风险增加与人类白细胞抗原（HLA）的特定表型有关。本研究旨在检测希腊人群中HLA特异性和单倍型与NPC的关联。在一项对53例患者的基因分型研究中，发现单倍型HLA - B5DR11与NPC之间存在显著关联，主要见于年龄大于45岁的患者。此外，上述单倍型与更长的无病生存期显著相关。与未分化型患者相比，鳞状细胞组织学患者中更常出现HLA - B5和HLA - B5DR11。这些结果表明，MHC基因座可能与希腊患者NPC的发病机制和预后有关。
