Carroll R S, Zhang J P, Black P M
Neurosurgical Laboratories, Brigham and Women's Hospital, Boston, USA.
Acta Neurochir (Wien). 1997;139(3):188-92; discussion 193. doi: 10.1007/BF01844749.
The possibility that steroid hormones play a role in vestibular schwannoma proliferation has been suggested by a number of investigators. There is conflicting information about the presence of steroid hormone receptors in these tumors. The aim of this study was to examine the expression of androgen, progesterone, glucocorticoid and estrogen receptor messenger ribonucleic acid levels (mRNA) in twenty-one vestibular schwannomas by either Northern blot analysis or the polymerase chain reaction (PCR). Glucocorticoid receptor mRNA was expressed in all twenty-one tumors examined. Only two male specimens were positive for androgen receptor mRNA expression by PCR-Southern blot analysis. Thirty-three percent of the schwannomas (7/21) showed a strong band for progesterone receptor mRNA by PCR-Southern blot analysis; there were an equal number of males and females in this group. Estrogen receptor mRNA levels were undetectable in all tumors examined by PCR-Southern blot analysis. These studies suggest that the pattern of steroid receptor expression is different in schwannomas than in meningiomas. Individual vestibular schwannomas need to be examined for their steroid receptor mRNA expression mRNA expression to know whether they will be responsive.
许多研究人员提出，类固醇激素可能在前庭神经鞘瘤增殖中发挥作用。关于这些肿瘤中类固醇激素受体的存在，存在相互矛盾的信息。本研究的目的是通过Northern印迹分析或聚合酶链反应（PCR）检测21例前庭神经鞘瘤中雄激素、孕激素、糖皮质激素和雌激素受体信使核糖核酸水平（mRNA）的表达。在所检测的21个肿瘤中均有糖皮质激素受体mRNA表达。通过PCR- Southern印迹分析，仅2例男性标本雄激素受体mRNA表达呈阳性。通过PCR- Southern印迹分析，33%的神经鞘瘤（7/21）显示孕激素受体mRNA有强条带；该组中男性和女性数量相等。通过PCR- Southern印迹分析，在所检测的所有肿瘤中均未检测到雌激素受体mRNA水平。这些研究表明，神经鞘瘤中类固醇受体的表达模式与脑膜瘤不同。需要对单个前庭神经鞘瘤进行类固醇受体mRNA表达检测，以了解它们是否有反应。
