体质指数与脑膜瘤、神经胶质瘤和神经鞘瘤风险的大型前瞻性队列研究（挪威亨于普研究）。
Body mass index and the risk of meningioma, glioma and schwannoma in a large prospective cohort study (The HUNT Study).
机构信息
Department of Neurosurgery, Oslo University Hospital, 0407 Oslo, Norway.
出版信息
Br J Cancer. 2013 Jul 9;109(1):289-94. doi: 10.1038/bjc.2013.304. Epub 2013 Jun 18.
BACKGROUND
Obesity increases the risk for a number of solid malignant tumours. However, it is not clear whether body mass index (BMI) and height are associated with the risk of primary tumours of the central nervous system (CNS).
METHODS
In a large population study (The Nord-Trøndelag Health Study (HUNT Study)) of 74 242 participants in Norway, weight and height were measured. During follow-up, incident CNS tumours were identified by individual linkage to the Norwegian Cancer Registry. Sex- and age-adjusted and multivariable Cox regression analyses were used to evaluate BMI and height in relation to the risk of meningioma, glioma and schwannoma.
RESULTS
A total of 138 meningiomas, 148 gliomas and 39 schwannomas occurred during 23.5 years (median, range 0-25) of follow-up. In obese women (BMI ≥ 30 kg m(-2)), meningioma risk was 67% higher (hazard ratio (HR)=1.68, 95% confidence interval (CI): 0.97-2.92, P-trend=0.05) than in the reference group (BMI 20-24.9 kg m(-2)), whereas no association with obesity was observed in males. There was no association of BMI with glioma risk, but there was a negative association of overweight/obesity (BMI ≥ 25 kg m(-2)) with the risk of schwannoma (HR=0.48, 95% CI: 0.23-0.99). However, the schwannoma analysis was based on small numbers. Height was not associated with the risk for any tumour subgroup.
CONCLUSION
These results suggest that BMI is positively associated with meningioma risk in women, and possibly, inversely associated with schwannoma risk.
背景
肥胖会增加多种实体恶性肿瘤的风险。然而，目前尚不清楚体重指数（BMI）和身高是否与中枢神经系统（CNS）原发性肿瘤的风险相关。
方法
在挪威一项针对 74242 名参与者的大型人群研究（北特伦德拉格健康研究（HUNT 研究））中，测量了体重和身高。在随访期间，通过与挪威癌症登记处的个体链接来确定 CNS 肿瘤的发病情况。采用性别和年龄调整的多变量 Cox 回归分析，评估 BMI 和身高与脑膜瘤、神经胶质瘤和神经鞘瘤风险的关系。
结果
在 23.5 年（中位数，范围 0-25）的随访期间，共发生 138 例脑膜瘤、148 例神经胶质瘤和 39 例神经鞘瘤。在肥胖女性（BMI≥30kg/m²）中，脑膜瘤风险增加 67%（风险比（HR）=1.68，95%置信区间（CI）：0.97-2.92，P 趋势=0.05），而男性中则未观察到肥胖与风险相关。BMI 与神经胶质瘤风险无关联，但超重/肥胖（BMI≥25kg/m²）与神经鞘瘤风险呈负相关（HR=0.48，95%CI：0.23-0.99）。然而，神经鞘瘤分析的基础是数量较少。身高与任何肿瘤亚组的风险均无关联。
结论
这些结果表明，BMI 与女性脑膜瘤风险呈正相关，并且可能与神经鞘瘤风险呈负相关。
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