Utsunomiya H, Ogasawara T, Hayashi T, Hashimoto T, Okazaki M
Department of Diagnostic Radiology, Fukuoka University Hospital, Japan.
Neuroradiology. 1997 Apr;39(4):302-10. doi: 10.1007/s002340050414.
We analysed the MRI findings in 23 patients with callosal dysgenesis in relation to their associated telencephalic anomalies to investigate the morphological significance of the development of Probst's bundles and the anterior commissure in congenital callosal dysgenesis. We classified callosal dysgenesis into three types: total defect (9 patients), partial defect (7) and hypoplasia (7). Associated anomalies were observed in 15 patients, including migration disorder (8 patients), micrencephaly (5), and lipoma (2). The remaining 8 patients had no associated anomalies. Probst's bundles were not identified in 4 patients with a severe migration disorder. An absent or hypoplastic anterior commissure was observed in 9 of the 16 patients with callosal defect and all 7 of those with callosal hypoplasia. Colpocephaly and keyhole dilatation of the temporal horns were seen in 16 and 21 patients, respectively. Callosal dysgenesis may occur not only through a defect in the callosal anlage, but also from impaired growth of axonal fibres projecting from the cerebral isocortex. Therefore, associated telencephalic anomalies may be responsible for additional features in callosal dysgenesis. Consequently, identification of Probst's bundles and the anterior commissure may be important when assessing cortical development in patients with callosal dysgenesis.
我们分析了23例胼胝体发育不全患者的MRI表现及其相关的端脑异常，以研究先天性胼胝体发育不全中普罗布斯特束和前连合发育的形态学意义。我们将胼胝体发育不全分为三种类型：完全缺如（9例）、部分缺如（7例）和发育不全（7例）。15例患者观察到相关异常，包括移行障碍（8例）、小脑畸形（5例）和脂肪瘤（2例）。其余8例患者无相关异常。4例严重移行障碍患者未发现普罗布斯特束。16例胼胝体缺如患者中有9例以及7例胼胝体发育不全患者均观察到前连合缺如或发育不全。分别在16例和21例患者中发现了脑室后部扩大和颞角匙孔样扩张。胼胝体发育不全不仅可能通过胼胝体原基的缺陷发生，还可能由于从大脑等皮质投射的轴突纤维生长受损所致。因此，相关的端脑异常可能是胼胝体发育不全其他特征的原因。因此，在评估胼胝体发育不全患者的皮质发育时，识别普罗布斯特束和前连合可能很重要。
