Matthieu L, Dockx P
Department of Dermatology, University Hospital Antwerp, Belgium.
Contact Dermatitis. 1997 Mar;36(3):150-1. doi: 10.1111/j.1600-0536.1997.tb00398.x.
Wondering why Amerchol L-101 (containing wool wax alcohols obtained from the hydrolysis of wool fat) appears as a test material (100%) in a cosmetics series (Chemotechnique Diagnostics AB), as wool wax alcohols were already tested in the European standard series, we added Amerchol L-101 (100%) systematically to the standard series. From 8 April 1991 to 28 February 1992, a total of 393 patients were tested: 3.05% (n = 12) showed positive test results (+, +2, +3) for wool wax alcohols as well as Amerchol L-101 (100%), 0.3% (n = 1) for wool wax alcohols only, and 11.1% (n = 44) for Amerchol L-101 (100%) only. Thus, the positive tests for Amerchol L-101 (100%) had a higher frequency of 3.4 compared to those for wool wax alcohols. In the meantime, we also added Amerchol L-101 50% (Trolab) to the standard series. Of all patients tested (n = 223) 2.7% (n = 6) had positive reactions to wool wax alcohols and 12.1% (n = 27) to Amerchol L-101 100% and/or 50%. Thus, positive reactions to Amerchol L-101 (100% and 50%) were 4.5 higher, whereas the rate of concordancy decreased. It is remarkable that 8 patients only had a positive reaction to Amerchol L-101 50% and 9 only to Amerchol L-101 100%. It seems that we miss many diagnoses in contact allergy by using only the standard wool wax alcohols test (30%).
想知道为什么在一个化妆品系列（Chemotechnique Diagnostics AB公司）中，Amerchol L - 101（含有从羊毛脂水解得到的羊毛蜡醇）作为一种测试材料（100%）出现，因为羊毛蜡醇已经在欧洲标准系列中进行过测试，我们将Amerchol L - 101（100%）系统地添加到标准系列中。从1991年4月8日至1992年2月28日，总共对393名患者进行了测试：3.05%（n = 12）对羊毛蜡醇以及Amerchol L - 101（100%）呈现阳性测试结果（+、+2、+3），仅对羊毛蜡醇呈阳性的为0.3%（n = 1），仅对Amerchol L - 101（100%）呈阳性的为11.1%（n = 44）。因此，Amerchol L - 101（100%）的阳性测试频率与羊毛蜡醇相比高出3.4倍。与此同时，我们还将50%的Amerchol L - 101（Trolab）添加到标准系列中。在所有接受测试的患者（n = 223）中，2.7%（n = 6）对羊毛蜡醇有阳性反应，12.1%（n = 27）对100%和/或50%的Amerchol L - 101有阳性反应。因此，对Amerchol L - 101（100%和50%）的阳性反应高出4.5倍，而一致性率下降。值得注意的是，8名患者仅对50%的Amerchol L - 101有阳性反应，9名患者仅对100%的Amerchol L - 101有阳性反应。似乎仅使用标准羊毛蜡醇测试（30%）会使我们错过许多接触性过敏的诊断。
