苦木素类衍生物对爱泼斯坦-巴尔病毒早期抗原激活的抑制作用。

Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation.

作者信息

Rahman S, Fukamiya N, Ohno N, Tokuda H, Nishino H, Tagahara K, Lee K H, Okano M

机构信息

Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1997 Apr;45(4):675-7. doi: 10.1248/cpb.45.675.

DOI:10.1248/cpb.45.675

PMID:9145503

Abstract

Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for semisynthetic quassinoids (3-7), which were obtained by esterification of the C-15 OH group of deacetylated isobrucein-B (2). All the ester derivatives showed higher antitumor promoting activity than that of the potent compound 2. A compound containing a fluorinated aliphatic ester showed the highest potency.

摘要

对通过去乙酰化异布鲁斯因-B（2）的C-15羟基酯化得到的半合成苦木素类化合物（3-7）进行了肿瘤启动子和抗肿瘤启动子的短期体外测定（爱泼斯坦-巴尔病毒激活试验）。所有酯衍生物均显示出比强效化合物2更高的抗肿瘤促进活性。一种含有氟化脂肪族酯的化合物显示出最高的活性。