Rahman S, Fukamiya N, Ohno N, Tokuda H, Nishino H, Tagahara K, Lee K H, Okano M
Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
Chem Pharm Bull (Tokyo). 1997 Apr;45(4):675-7. doi: 10.1248/cpb.45.675.
Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for semisynthetic quassinoids (3-7), which were obtained by esterification of the C-15 OH group of deacetylated isobrucein-B (2). All the ester derivatives showed higher antitumor promoting activity than that of the potent compound 2. A compound containing a fluorinated aliphatic ester showed the highest potency.
对通过去乙酰化异布鲁斯因-B（2）的C-15羟基酯化得到的半合成苦木素类化合物（3-7）进行了肿瘤启动子和抗肿瘤启动子的短期体外测定（爱泼斯坦-巴尔病毒激活试验）。所有酯衍生物均显示出比强效化合物2更高的抗肿瘤促进活性。一种含有氟化脂肪族酯的化合物显示出最高的活性。
