苦木素类化合物对爱泼斯坦-巴尔病毒激活的抑制作用。

Inhibitory effects of quassinoids on Epstein-Barr virus activation.

作者信息

Okano M, Fukamiya N, Tagahara K, Tokuda H, Iwashima A, Nishino H, Lee K H

机构信息

Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.

出版信息

Cancer Lett. 1995 Aug 1;94(2):139-46. doi: 10.1016/0304-3835(95)03839-o.

DOI:10.1016/0304-3835(95)03839-o

PMID:7634241

Abstract

Short-term in vitro assays for tumor promoters and anti-tumor promoters (Epstein-Barr virus activation test) were carried out for 45 quassinoids. As a result, some quassinoids showed potent activity, more than 50% inhibition at a molar ratio of 1:1 (TPA/quassinoids). These results led to the following structure-activity relationships: (1) a methyleneoxy bridge and side chain enhance the activity and (2) a sugar moiety reduces the activity.

摘要

对45种苦木素类化合物进行了肿瘤启动子和抗肿瘤启动子的短期体外测定（爱泼斯坦-巴尔病毒激活试验）。结果显示，一些苦木素类化合物表现出较强的活性，在摩尔比为1:1（TPA/苦木素类化合物）时抑制率超过50%。这些结果得出了以下构效关系：（1）亚甲氧基桥和侧链增强活性；（2）糖部分降低活性。