O'Leary M P, Sant G R, Fowler F J, Whitmore K E, Spolarich-Kroll J
Department of Surgery, Harvard Medical School, Boston, MA, USA.
Urology. 1997 May;49(5A Suppl):58-63. doi: 10.1016/s0090-4295(99)80333-1.
To develop 2 brief self-administered indices for measuring lower urinary tract symptoms and their impact in patients with interstitial cystitis (IC).
An initial set of questions was developed and evaluated in focus groups. The index was revised, shortened, and validated with patients diagnosed in 3 large urologic practices with experience in interstitial cystitis (N = 45). Controls were recruited from a group of healthy volunteers in a gynecology clinic (N = 67). Internal consistency, construct validity, and test-retest reliability were evaluated.
The IC symptom index and the IC problem index measure urinary and pain symptoms and assesses how problematic symptoms are for patients with interstitial cystitis. Psychometric performance of both instruments is good, with the symptom index demonstrating excellent ability to discriminate characteristics between patients and controls.
Both indices should be useful in the evaluation and management of patients with IC and should be particularly useful in clinical trials of new therapies for this condition, where reliable, validated, and reproducible outcome measures are critically important.
制定2个简短的自我管理指标，用于测量间质性膀胱炎（IC）患者的下尿路症状及其影响。
初步设计了一组问题并在焦点小组中进行评估。该指标经过修订、缩短，并在3家有间质性膀胱炎诊疗经验的大型泌尿外科诊所确诊的患者中进行了验证（N = 45）。对照组从一家妇科诊所的一组健康志愿者中招募（N = 67）。评估了内部一致性、结构效度和重测信度。
IC症状指标和IC问题指标可测量泌尿和疼痛症状，并评估这些症状对间质性膀胱炎患者的问题程度。两种工具的心理测量性能良好，症状指标显示出区分患者和对照组特征的卓越能力。
这两个指标在IC患者的评估和管理中都应有用，并且在针对这种疾病的新疗法的临床试验中应特别有用，在这些试验中，可靠、经过验证且可重复的结果测量至关重要。
