Chin M H, Goldman L
Department of Medicine, Brigham and Women's Hospital, Boston, Mass, USA.
Am J Public Health. 1997 Apr;87(4):643-8. doi: 10.2105/ajph.87.4.643.
This study identifies acute precipitants of hospitalization and evaluates utilization of angiotension-converting enzyme inhibitors in patients admitted with congestive heart failure.
Cross-sectional chart-review study was done of 435 patients admitted nonelectively from February 1993 to February 1994 to an urban university hospital with a complaint of shortness of breath or fatigue and evidence of congestive heart failure.
The most common identifiable abnormalities associated with clinical deterioration prior to admission were acute anginal chest pain (33%), respiratory infection (16%), uncontrolled hypertension with initial systolic blood pressure > or = 180 mm Hg (15%), atrial arrhythmia with heart rate > or = 120 (8%), and noncompliance with medications (15%) or diet (6%); in 34% of patients, no clear cause could be identified. After exclusion of those who were already on a different vasodilator or who had relative contraindications, 18 (32%) of the patients with ejection fractions < or = 0.35 measured prior to admission were not taking an angiotensin-converting enzyme inhibitor on presentation to the hospital.
Interventions to improve compliance, the control of hypertension, and the appropriate use of angiotensin-converting enzyme inhibitors may prevent many hospitalizations of heart-failure patients.
本研究旨在确定住院的急性诱发因素,并评估充血性心力衰竭患者血管紧张素转换酶抑制剂的使用情况。
对1993年2月至1994年2月间因呼吸急促或疲劳主诉且有充血性心力衰竭证据而无选择性入住一家城市大学医院的435例患者进行横断面图表回顾研究。
入院前与临床病情恶化相关的最常见可识别异常情况为急性心绞痛(33%)、呼吸道感染(16%)、初始收缩压≥180 mmHg的未控制高血压(15%)、心率≥120的房性心律失常(8%)以及药物治疗(15%)或饮食(6%)不依从;34%的患者未发现明确病因。排除那些已在使用其他血管扩张剂或有相对禁忌证的患者后,入院前测得射血分数≤0.35的患者中有18例(32%)在入院时未服用血管紧张素转换酶抑制剂。
改善依从性、控制高血压以及合理使用血管紧张素转换酶抑制剂的干预措施可能预防许多心力衰竭患者的住院治疗。