胚胎移植时的发育阶段会影响卵胞浆内单精子注射治疗的结果。
Embryo developmental stage at transfer influences outcome of treatment with intracytoplasmic sperm injection.
作者信息
Zhu J, Meniru G I, Craft I L
机构信息
London Gynaecology & Fertility Centre, UK.
出版信息
J Assist Reprod Genet. 1997 May;14(5):245-9. doi: 10.1007/BF02765824.
PURPOSE
Our purpose was to determine if embryo cell stage at the time of intrauterine transfer correlates with pregnancy rate in patients treated with intracytoplasmic sperm injection (ICSI).
METHODS
We conducted a retrospective analysis of 455 embryo transfer cycles following ICSI and 304 conventional in vitro fertilization (IVF) and embryo transfer cycles in women aged 40 years or less. Abstracted information included grading of the embryo cell stage and quality at the time of transfer.
RESULTS
The overall ICSI pregnancy rate was 30.8%, while that of conventional IVF was 29.3%. However, the ICSI pregnancy rate fell to 9.3% for embryo transfers taking place at the two-cell stage but increased to 35.8% when at least one embryo had more than two cells, and this difference was statistically significant (P < or = 0.0001). The pregnancy rate following conventional IVF was 22.0% when only two-cell embryos were transferred and 32.0% when at least one of the embryos had more than two cells, but this difference in pregnancy rates was not significant (P > 0.05).
CONCLUSIONS
The stage of embryo development at transfer appears to exert a powerful influence on the successful establishment of pregnancy after ICSI.
目的
我们的目的是确定在接受卵胞浆内单精子注射（ICSI）治疗的患者中，子宫内移植时的胚胎细胞阶段是否与妊娠率相关。
方法
我们对455个ICSI后的胚胎移植周期以及304个40岁及以下女性的传统体外受精（IVF）和胚胎移植周期进行了回顾性分析。提取的信息包括移植时胚胎细胞阶段的分级和质量。
结果
ICSI的总体妊娠率为30.8%，而传统IVF的妊娠率为29.3%。然而，在两细胞阶段进行胚胎移植时，ICSI的妊娠率降至9.3%，但当至少有一个胚胎的细胞数超过两个时，妊娠率升至35.8%，这种差异具有统计学意义（P≤0.0001）。在传统IVF中，仅移植两细胞胚胎时的妊娠率为22.0%，当至少有一个胚胎的细胞数超过两个时，妊娠率为32.0%，但妊娠率的这种差异不显著（P>0.05）。
结论
移植时胚胎发育阶段似乎对ICSI后妊娠的成功建立有很大影响。
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