宫颈内授精技术与宫腔内授精技术在供精人工授精后多胎妊娠发生率方面的作用比较。
Comparison of the role of cervical and intrauterine insemination techniques on the incidence of multiple pregnancy after artificial insemination with donor sperm.
作者信息
Tur R, Buxaderas C, Martínez F, Busquets A, Coroleu B, Barri P N
机构信息
Department of Obstetrics and Gynaecology, Institut Dexeus, Barcelona, Spain.
出版信息
J Assist Reprod Genet. 1997 May;14(5):250-3. doi: 10.1007/BF02765825.
PURPOSE
Our purpose was to investigate the role of the insemination technique used in an artificial insemination program with donor sperm (AID) in multiple pregnancy rates.
METHODS
We carried out a retrospective nonrandom analysis of 300 pregnancies corresponding to 300 cycles in women from our Artificial Insemination Donor Sperm Program. All cycles were stimulated with gonadotropins. Single and multiple pregnancy cycles and intracervical and intrauterine pregnant cycles were compared.
RESULTS
Intracervical insemination was performed in 173 cycles (58%), and intrauterine insemination in 127 (42%). Two hundred twenty-three pregnancies were single (74%), and 77 multiple (26%). In multiple pregnancy cycles, initial dose and mean total daily dose of gonadotropins, plasma estradiol levels, and number of follicles > or = 14 mm were significantly higher compared to those in single pregnancy cycles. Multiple pregnancy rte was significantly higher among pregnancies after intrauterine insemination (32%) than after intracervical insemination (21%).
CONCLUSIONS
The intrauterine technique of insemination in AID-stimulated cycles with gonadotropins is related to multiple pregnancy risk.
目的
我们的目的是研究在使用供体精子的人工授精计划（AID）中所采用的授精技术对多胎妊娠率的影响。
方法
我们对来自我们的供体精子人工授精计划的300例妊娠（对应300个周期）的女性进行了回顾性非随机分析。所有周期均用促性腺激素进行刺激。比较了单胎和多胎妊娠周期以及宫颈内和子宫内妊娠周期。
结果
173个周期（58%）进行了宫颈内授精，127个周期（42%）进行了子宫内授精。223例妊娠为单胎（74%），77例为多胎（26%）。在多胎妊娠周期中，与单胎妊娠周期相比，促性腺激素的初始剂量和平均每日总剂量、血浆雌二醇水平以及直径≥14mm的卵泡数量显著更高。子宫内授精后的妊娠多胎妊娠率（32%）显著高于宫颈内授精后的妊娠多胎妊娠率（21%）。
结论
在使用促性腺激素刺激的AID周期中，子宫内授精技术与多胎妊娠风险相关。
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