Ryzhenkov V E, Solov'eva M A, Remezova O V, Okunevich I V
Vopr Med Khim. 1996 Apr-Jun;42(2):115-9.
In experiments on hyperlipidemic rats it was observed the hypolipidemic effect of new sulfated polisaccharides-chitosan, lutelan and krilan sulfates, More pronounced decrease was established in VLDL and increase of HDL after sulfated polysaccharides treatment. The most distinct efficiency exhibites preparation with moledular mass of 20-40 x 10(3) D and the rate of sulfation 9-14%.
在对高脂血症大鼠的实验中，观察到了新型硫酸化多糖——壳聚糖、硫酸鲁特兰聚糖和硫酸克里兰聚糖的降血脂作用。硫酸化多糖处理后，极低密度脂蛋白（VLDL）有更明显的降低，高密度脂蛋白（HDL）有所增加。分子量为20 - 40×10³D且硫酸化率为9 - 14%的制剂表现出最显著的效果。
