Akesode A, Migeon C J, Kowarski A A
J Clin Endocrinol Metab. 1977 Oct;45(4):849-52. doi: 10.1210/jcem-45-4-849.
The effect of eating on the metabolic clearance rate (MCR) of aldosterone was investigated in 10 adult individuals. 3H-aldosterone was infused continuously over a period of 5 h while the subjects remained supine. Three h after the start of the infusion, each subject ate a bowl of soup. The MCR of aldosterone, before and after the intake of food, was calculated by dividing the rate of infusion of 3H-aldosterone by the mean concentration of under the same conditions but without eating. The MCR of aldosterone (mean +/- 1 SD) was 1284 +/- 513 L/24 h before food intake and 2182 +/- 180 L/24 h after food intake in the 10 individuals who ate. The MCR in the 11 subjects who did not eat was 1363 +/- 446 and 1357 +/- 434 during the same periods (p greater than 0.05). The 29% increase in the MCR induced by eating was highly significant (p less than 0.001); it was similar in magnitude and duration to a previously reported effect of food intake on the hepatic blood flow (13).
在10名成年个体中研究了进食对醛固酮代谢清除率（MCR）的影响。在受试者保持仰卧位的情况下，持续5小时输注³H-醛固酮。输注开始3小时后，每位受试者吃一碗汤。通过将³H-醛固酮的输注速率除以相同条件下但未进食时的平均浓度，计算进食前后醛固酮的MCR。在进食的10名个体中，进食前醛固酮的MCR（平均值±1标准差）为1284±513L/24小时，进食后为2182±180L/24小时。11名未进食的受试者在相同时间段内的MCR分别为1363±446和1357±434（p＞0.05）。进食引起的MCR升高29%具有高度显著性（p＜0.001）；其幅度和持续时间与先前报道的食物摄入对肝血流量的影响相似（13）。
