Giry J, Delost P
Reprod Nutr Dev (1980). 1980;20(1B):271-6.
Aldosterone-binding to plasma proteins was determined in the guinea-pig by equilibrium dialysis, and the metabolic clearance rate (MCR) of aldosterone was calculated from experiments in which the labelled hormone was infused at a constant rate into the circulation during the neonatal period; no specific aldosterone-binding protein was found in the plasma. The hormone was weakly bound to the albumine. The MCR of aldosterone (1/day/100 g body weight) was unchanged from birth to day 8, and its values were similar to those found in adults. Since there was no modification in aldosterone-binding to plasma proteins and no change in the MCR from birth to day 3, the high plasma aldosterone concentrations in the guinea-pig were probably related to intense adrenal activity.
通过平衡透析法测定了豚鼠血浆蛋白与醛固酮的结合情况，并根据新生期以恒定速率向循环系统输注标记激素的实验计算了醛固酮的代谢清除率（MCR）；未在血浆中发现特异性醛固酮结合蛋白。该激素与白蛋白结合较弱。醛固酮的MCR（1/天/100克体重）从出生到第8天没有变化，其值与成年豚鼠相似。由于从出生到第3天醛固酮与血浆蛋白的结合没有改变，MCR也没有变化，因此豚鼠血浆中醛固酮浓度较高可能与肾上腺活动强烈有关。
