Hegde U M, White J M, Hart G H, Marsh G W
J Clin Pathol. 1977 Sep;30(9):884-9. doi: 10.1136/jcp.30.9.884.
A number of patients of Mediterranean and Asian origins were found to have unexplained microcytic hypochromic red blood cells. Iron deficiency and beta-thalassaemia trait were both satisfactorily excluded in all of them. The haematological indices of these patients, obtained on a Coulter Model 'S' Counter, were found to be very similar to those seen in obligatory heterozygotes for alpha-thalassaemia. It is postulated that these patients were also carriers for alpha-thalassaemia. Subsequent investigation of some of these patients showed the characteristically reduced rates of alpha-chain synthesis seen in this condition. The discriminant function of England and Fraser (1973) may be of help in diagnosing this state. alpha-Thalassaemia trait should be considered in all patients of 'high-risk' ethnic origins with a blood picture suggestive of beta-thalassaemia trait but in whom the levels of Hb A2 and Hb F are within normal limits.
发现许多地中海和亚洲血统的患者存在不明原因的小细胞低色素性红细胞。所有患者均已令人满意地排除了缺铁和β地中海贫血特征。使用库尔特“S”型计数器获得的这些患者的血液学指标，发现与α地中海贫血的必需杂合子所见指标非常相似。据推测，这些患者也是α地中海贫血的携带者。随后对其中一些患者的调查显示，在这种情况下α链合成速率明显降低。英格兰和弗雷泽（1973年）的判别函数可能有助于诊断这种状态。对于所有具有提示β地中海贫血特征的血象但Hb A2和Hb F水平在正常范围内的“高危”种族起源患者，均应考虑α地中海贫血特征。
