免疫功能正常的全身性单纯疱疹感染患者的视网膜血管周围炎。
Retinal perivasculitis in an immunocompetent patient with systemic herpes simplex infection.
作者信息
Chatzoulis D M, Theodosiadis P G, Apostolopoulos M N, Drakoulis N, Markomichelakis N N
机构信息
Department of Ophthalmology, School of Medicine, Athens University, Greece.
出版信息
Am J Ophthalmol. 1997 May;123(5):699-702. doi: 10.1016/s0002-9394(14)71089-x.
PURPOSE
To describe a case of retinal perivasculitis in an immunocompetent patient with systemic herpes simplex infection.
METHODS
Polymerase chain reaction amplifications were performed for aqueous and blood samples using primers specific for the following members of the herpesvirus family: cytomegalovirus, Epstein-Barr virus, herpes simplex virus (types 1 and 2), and varicella-zoster virus. The patient was placed on intravenous acyclovir and systemic corticosteroids.
RESULTS
A positive polymerase chain reaction signal was found only for herpes simplex virus type 1. Vision in the left eye improved from light perception to 20/25, and signs of retinal perivasculitis resolved.
CONCLUSION
The use of molecular diagnostic modalities in clinical practice may aid in determining infectious etiologies in patients with atypical clinical manifestations.
目的
描述一例免疫功能正常的全身性单纯疱疹感染患者发生视网膜血管周围炎的病例。
方法
使用针对疱疹病毒科以下成员的特异性引物对房水和血液样本进行聚合酶链反应扩增：巨细胞病毒、爱泼斯坦-巴尔病毒、单纯疱疹病毒（1型和2型）以及水痘-带状疱疹病毒。该患者接受了静脉注射阿昔洛韦和全身性皮质类固醇治疗。
结果
仅发现1型单纯疱疹病毒的聚合酶链反应信号呈阳性。左眼视力从光感提高到20/25，视网膜血管周围炎的体征消失。
结论
在临床实践中使用分子诊断方法可能有助于确定临床表现不典型患者的感染病因。
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